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Titolo:
REGULATION OF RAT-BRAIN VESICULAR MONOAMINE TRANSPORTER BY CHRONIC TREATMENT WITH OVARIAN HORMONES
Autore:
REHAVI M; GOLDIN M; ROZ N; WEIZMAN A;
Indirizzi:
TEL AVIV UNIV,SACKLER FAC MED,DEPT PHYSIOL & PHARMACOL IL-69978 TEL AVIV ISRAEL TEL AVIV UNIV,SACKLER FAC MED,GEHA PSYCHIAT HOSP IL-69978 TEL AVIV ISRAEL TEL AVIV UNIV,SACKLER FAC MED,FELSENSTEIN MED RES CTR IL-69978 TEL AVIV ISRAEL
Titolo Testata:
Molecular brain research
fascicolo: 1, volume: 57, anno: 1998,
pagine: 31 - 37
SICI:
0169-328X(1998)57:1<31:RORVMT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESTROGEN-TREATMENT; SYNAPTIC VESICLE; H-3 DIHYDROTETRABENAZINE; CHROMAFFIN GRANULES; DOPAMINE RELEASE; CORPUS STRIATUM; CLONING; PROGESTERONE; EXPRESSION;
Keywords:
VESICULAR MONOAMINE TRANSPORTER; ESTRADIOL; PROGESTERONE; [H-3]DIHYDROTETRABENAZINE; SEROTONIN; DOPAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
M. Rehavi et al., "REGULATION OF RAT-BRAIN VESICULAR MONOAMINE TRANSPORTER BY CHRONIC TREATMENT WITH OVARIAN HORMONES", Molecular brain research, 57(1), 1998, pp. 31-37

Abstract

Ovarian steroids play an important role in neuroregulation and in thepathophysiology of various neuropsychiatric disorders. Most of the studies focused on the impact of gonadal steroids on post-synaptic receptors and plasma membrane transporters. In the present study, we evaluated the effect of chronic treatment with ovarian steroids on the expression of rat brain vesicular monoamine transporter (VMAT(2)). Ovariectomized rats were treated for 21 days with estradiol, progesterone or both. VMAT(2) gene expression was assessed on the protein level by highaffinity [H-3]dihydrotetrabenazine ([H-3]TBZOH) binding using autoradiography and on the mRNA level by in situ hybridization. Progesterone administration led to a decrease in [H-3]TBZOH binding in the middle striatum and in the nucleus accumbens and to a parallel decrease in VMAT(2) mRNA level in the substantia nigra pars compacts and dorsal raphenuclei. Chronic estradiol treatment reduced VMAT(2) mRNA level in thedorsal raphe and [H-3]TBZOH binding in middle part of the striatum and nucleus accumbens but did not affect VMAT(2) mRNA level in the substantia nigra pars compacta. Simultaneous administration of both ovariansteroids did not modulate VMAT(2) mRNA in the substantia nigra pars compacta as well as [H-3]TBZOH binding in the striatum or the nucleus accumbens but reduced VMAT(2) mRNA level in the dorsal raphe. It appears that ovarian steroids may play a crucial role in the regulation of VMAT(2) gene expression in the dopamine and serotonin systems. This modulatory activity may be relevant to synaptic and neuronal plasticity as well as to the molecular and cellular pathophysiology of gender-specific neuropsychiatric disorders. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:12:52