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Titolo:
STRESS-INDUCED SHEDDING OF A TUMOR-ANTIGEN BY A RAT HISTIOCYTIC CELL-LINE AK-5 - A POSSIBLE MECHANISM OF IMMUNE EVASION
Autore:
GOPALKRISHNA P; BEGUM Z; KHAR A;
Indirizzi:
CTR CELLULAR & MOL BIOL,UPPAL RD HYDERABAD 500007 ANDHRA PRADESH INDIA CTR CELLULAR & MOL BIOL HYDERABAD 500007 ANDHRA PRADESH INDIA
Titolo Testata:
Cellular and molecular biology
fascicolo: 4, volume: 44, anno: 1998,
pagine: 563 - 569
SICI:
0145-5680(1998)44:4<563:SSOATB>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUS IMMUNOLOGICAL REGRESSION; CANCER-CELLS; ANTIBODY; PROTEINS; GROWTH;
Keywords:
ANTIGEN SHEDDING; RAT HISTIOCYTOMA; IMMUNE EVASION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
P. Gopalkrishna et al., "STRESS-INDUCED SHEDDING OF A TUMOR-ANTIGEN BY A RAT HISTIOCYTIC CELL-LINE AK-5 - A POSSIBLE MECHANISM OF IMMUNE EVASION", Cellular and molecular biology, 44(4), 1998, pp. 563-569

Abstract

AK-5 is a highly immunogenic tumor which stimulates multiple arms of the host immune system. Tumor cells when transplanted subcutaneously grow as solid tumors which are regressed in about 70% of animals, whereas 100% i.p. transplanted animals succumb to the tumor growth. In the present study we demonstrate shedding of an antigen by AK-5 cells whensubjected to stress such as low cell number transplantation in vivo, heat shock and serum starvation in vitro. The shed antigen is able to neutralize antitumor antibody in a complement fixation assay. The antigen is also detected in the cell-free ascitic fluid. The size of the shed antigen as recognized by anti-AK-5 antibody is approximate to 45 kDa. We have also studied some of the biochemical characteristics of the purified shed antigen. These observations suggest a positive role for the AK-5 antigen in immune recognition which is lost in i.p. transplanted tumor cells due to the shedding of the antigen, thereby escapingthe immune invasion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 14:08:02