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Titolo:
EFFECT OF PARTIAL ARRHYTHMIA SUPPRESSION WITH AMIODARONE ON HEART-RATE-VARIABILITY OF PATIENTS WITH CONGESTIVE-HEART-FAILURE
Autore:
ROHDE LEP; POLANCZYK CA; MORAES RS; FERLIN E; RIBEIRO JP;
Indirizzi:
HOSP CLIN PORTO ALEGRE,SERV CARDIOL,DIV CARDIOL,RUA RAMIRO BARCELOS 2350 BR-90035007 PORTO ALEGRE RS BRAZIL HOSP CLIN PORTO ALEGRE,SERV CARDIOL,DIV CARDIOL BR-90035007 PORTO ALEGRE RS BRAZIL HOSP CLIN PORTO ALEGRE,BIOMED ENGN DIV PORTO ALEGRE RS BRAZIL UNIV FED RIO GRANDE SUL,SCH MED,DEPT MED PORTO ALEGRE RS BRAZIL
Titolo Testata:
The American heart journal
fascicolo: 1, volume: 136, anno: 1998,
pagine: 31 - 36
SICI:
0002-8703(1998)136:1<31:EOPASW>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIAC PARASYMPATHETIC ACTIVITY; CORONARY-ARTERY DISEASE; SPECTRAL-ANALYSIS; MYOCARDIAL-INFARCTION; VENTRICULAR ARRHYTHMIAS; FREQUENCY-DOMAIN; SECONDARY; MORTALITY; STABILITY; DIGOXIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
L.E.P. Rohde et al., "EFFECT OF PARTIAL ARRHYTHMIA SUPPRESSION WITH AMIODARONE ON HEART-RATE-VARIABILITY OF PATIENTS WITH CONGESTIVE-HEART-FAILURE", The American heart journal, 136(1), 1998, pp. 31-36

Abstract

Background Some antiarrythmic agents that may increase mortality rates have been shown to reduce heart rate variability in patients with heart failure. Amiodarone is a potent antiarrhythmic agent that may reduce mortality rates in heart failure, but little is known about its effects on heart rate variability. Methods and Results The purpose of this study was to evaluate the effect of partial arrhythmia suppression by amiodarone on indexes of heart rate variability in patients with heart failure. Ten clinically stable patients in New York Heart Association class II-III received amiodarone during a 4-week period (600 mg every day for 14 days and 300 mg every day for 16 days), and 24-hour Holter recordings were performed before and after treatment. Heart rate variability indexes were calculated by a semiautomatic method that applies a 20% filter to the temporal series, excluding ectopy and compensatory pauses. After amiodarone administration, there was a significant reduction in pNN50 from 8% +/- 7% to 3% +/- 2% (p < 0.05) and there wasa trend toward reduction in rMSSD (p = 0.06). Other time domain indexes did not change significantly. Spec tral analysis demonstrated a significant reduction of low-frequency components (421 +/- 122 to 151 +/-25 msec(2); p < 0.05) and total power (1503 +/- 314 to 609 +/- 144 msec(2), P < 0.05). Multivariate analysis showed that the observed reduction in pNN50 was strongly associated with the number and the reduction of ventricular premature contractions before and after amiodarone administration (r(2) = 0.94; p < 0.01). Conclusions These findings indicate that despite the use of software corrections for arrhythmia, short-term time domain indexes of heart rate variability may be effected bypartial suppression of ectopy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 09:46:58