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Titolo:
THE INTERACTION OF CLASS-B G-PROTEIN-COUPLED RECEPTORS WITH THEIR HORMONES
Autore:
HORN F; BYWATER R; KRAUSE G; KUIPERS W; OLIVEIRA L; PAIVA ACM; SANDER C; VRIEND G;
Indirizzi:
EUROPEAN MOL BIOL LAB,MEYERHOFSTR 1 D-69117 HEIDELBERG GERMANY EUROPEAN MOL BIOL LAB D-69117 HEIDELBERG GERMANY NOVO NORDISK AS,DEPT BIOSTRUCT MALOV 2760 DENMARK FORSCHUNGSINST MOL PHARMAKOL D-10315 BERLIN GERMANY SOLVAY DUPHAR MED CHEM NL-1380 DA WEESP NETHERLANDS ESCOLA PAULISTA MED,DEPT BIOFIS BR-04034 SAO PAULO BRAZIL EUROPEAN BIOINFORMAT INST CAMBRIDGE CB10 1SD ENGLAND
Titolo Testata:
Receptors & channels
fascicolo: 5, volume: 5, anno: 1998,
pagine: 305 - 314
SICI:
1060-6823(1998)5:5<305:TIOCGR>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
TERMINAL EXTRACELLULAR DOMAIN; GLUCAGON-LIKE PEPTIDE-1; PARATHYROID-HORMONE; METAPHYSEAL CHONDRODYSPLASIA; SECRETIN RECEPTOR; RESIDUES; BINDING; MUTATIONS; DATABASE; MUTANTS;
Keywords:
CLASS B RECEPTORS; COMPUTATIONAL BIOLOGY; CORRELATED MUTATION; GPCR; G PROTEIN-COUPLED RECEPTOR; RECEPTOR-LIGAND INTERACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
F. Horn et al., "THE INTERACTION OF CLASS-B G-PROTEIN-COUPLED RECEPTORS WITH THEIR HORMONES", Receptors & channels, 5(5), 1998, pp. 305-314

Abstract

In common with many G protein-coupled receptors, dysfunction in members of the Class B or glucagon-like receptors can elicit a wide spectrum of disease related activities. Consequently, they an potential targets in many different areas of pharmacological research. Unlike the class A or rhodopsin-like receptors, for which at least some structural similarity to bacteriorhodopsin has been detected, absolutely no structural information is available for the Class B G protein-coupled receptors, We present a computational study that exploits the experimental work performed by evolution to indicate residues that are potentially involved in ligand binding in the Class B G protein-coupled receptors. We perform an analysis of mutations that occurred in a correlated fashion between the receptors and their peptidic ligands, The inference that the residues detected in this manner are involved in a direct interaction between the receptor and the ligand is in good agreement with the mutation studies that have already been published.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 01:40:42