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Titolo:
ITAMS - IMMUNOREGULATORY SCAFFOLDS THAT LINK IMMUNORECEPTORS TO THEIRINTRACELLULAR SIGNALING PATHWAYS
Autore:
ISAKOV N;
Indirizzi:
BEN GURION UNIV NEGEV,FAC HLTH SCI,DEPT MICROBIOL & IMMUNOL,POB 653 IL-84105 BEER SHEVA ISRAEL BEN GURION UNIV NEGEV,CTR CANC RES IL-84105 BEER SHEVA ISRAEL
Titolo Testata:
Receptors & channels
fascicolo: 5, volume: 5, anno: 1998,
pagine: 243 - 253
SICI:
1060-6823(1998)5:5<243:I-ISTL>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL ANTIGEN RECEPTOR; PROTEIN-TYROSINE KINASE; TANDEM SH2 DOMAINS; PHOSPHORYLATED IG-ALPHA; SEVERE COMBINED IMMUNODEFICIENCY; SOLID-PHASE SYNTHESIS; FC-GAMMA-RIIB; T-CELL; ZETA-CHAIN; ACTIVATION MOTIF;
Keywords:
ITAM; LYMPHOCYTE ACTIVATION; PROTEIN TYROSINE KINASE; SH2; SIGNAL TRANSDUCTION; TYROSINE PHOSPHORYLATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
94
Recensione:
Indirizzi per estratti:
Citazione:
N. Isakov, "ITAMS - IMMUNOREGULATORY SCAFFOLDS THAT LINK IMMUNORECEPTORS TO THEIRINTRACELLULAR SIGNALING PATHWAYS", Receptors & channels, 5(5), 1998, pp. 243-253

Abstract

Antigen receptors on the surface of T and B lymphocytes and various immunoglobulin Fc receptors are complexed multi-subunit structures thatpossess unique cytoplasmic modules, termed immunoreceptor tyrosine-based activation motif (ITAM), These modules consist of two repeats of the conserved sequence Tyr-X-X-Leu/lle spaced by six-to-eight residues and they function as 'on and off' switches that link the receptors to their intracellular signaling machinery. Thus, engagement of ITAM-containing receptors results in a rapid and transient phosphorylation of the ITAMs' tyrosine residues that function as temporal scaffolds for Src homology 2 (SH2) domains of downstream effector molecules. Recruitment and binding of these molecules to phospho-ITAMs initiate a cascade of biochemical events that lead to cell proliferation, differentiation, and acquisition of unique effector functions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/10/20 alle ore 00:58:17