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Titolo:
THE ROLE OF CORTICOTROPIN-RELEASING FACTOR IN DEPRESSIVE-ILLNESS - A CRITICAL-REVIEW
Autore:
MITCHELL AJ;
Indirizzi:
ADDENBROOKES HOSP,DEPT LIAISON PSYCHIAT,BOX 175 CAMBRIDGE CB2 2QQ ENGLAND
Titolo Testata:
Neuroscience and biobehavioral reviews
fascicolo: 5, volume: 22, anno: 1998,
pagine: 635 - 651
SICI:
0149-7634(1998)22:5<635:TROCFI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-ADRENAL AXIS; FACTOR-LIKE IMMUNOREACTIVITY; CENTRAL-NERVOUS-SYSTEM; CEREBROSPINAL-FLUID CONCENTRATIONS; RAT-BRAIN REGIONS; MAJOR DEPRESSION; MESSENGER-RNA; FACTOR CRF; ALZHEIMERS-DISEASE; FACTOR RECEPTORS;
Keywords:
CORTICOTROPIN-RELEASING FACTOR/HORMONE; DEPRESSION; HPA AXIS; CEREBROSPINAL FLUID; GLUCOCORTICOID RECEPTORS; CRF RECEPTORS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
154
Recensione:
Indirizzi per estratti:
Citazione:
A.J. Mitchell, "THE ROLE OF CORTICOTROPIN-RELEASING FACTOR IN DEPRESSIVE-ILLNESS - A CRITICAL-REVIEW", Neuroscience and biobehavioral reviews, 22(5), 1998, pp. 635-651

Abstract

Corticotropin-releasing factor (CRF) is the principal neuropeptide involved in regulating the stress response. When centrally administered to animals it produces somatic changes analogous to those seen in bothdepression and anxiety. In humans, it is capable of reproducing the hormonal changes which are characteristically seen in depressed patients. A literature search using Medline, Embase Psychiatry, PsycLIT and BIDS from 1966-1997 revealed 25 studies that have examined CRF concentrations in patients with affective disorder. The methodology of these studies varies and they can be criticised, in particular, for failing to consider the stress response of the lumbar puncture. Recently, post-mortem immunocytochemical techniques have been employed to help clarify the nature of these abnormalities in depression. On balance, evidence from CSF sampling, post-mortem findings and dynamic endocrine studies suggests that both hypothalamic and extra-hypothalamic concentrations of CRF are moderately elevated in a proportion of currently depressed patients. Which, if either, of these anatomical areas has more clinical significance is unknown, although after effective antidepressant treatment, high CRF concentrations tend to normalise. The causes of increased CRF output in depression are also unknown but may involve an integration of remote vulnerability factors and recent stressors perhapsmediated through impaired function of glucocorticoid receptors. Ultimately, the careful manipulation of CRF may hold therapeutic promise for sufferers of mood disorders. (C) 1998 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 01:01:10