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Titolo:
A VERY-LOW DOSE OF GREEN TEA POLYPHENOLS IN DRINKING-WATER PREVENTS N-METHYL-N-NITROSOUREA-INDUCED COLON CARCINOGENESIS IN F344 RATS
Autore:
NARISAWA T; FUKAURA Y;
Indirizzi:
AKITA UNIV,COLL ALLIED MED SCI,HONDO 1-1-1 AKITA 010 JAPAN
Titolo Testata:
Japanese journal of cancer research
fascicolo: 10, volume: 84, anno: 1993,
pagine: 1007 - 1009
SICI:
0910-5050(1993)84:10<1007:AVDOGT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR INITIATION; PROTECTION; FRACTION; CANCER; JAPAN; SKIN; MICE;
Keywords:
COLON CANCER; COLON CARCINOGENESIS; TEA POLYPHENOL; GREEN TEA; CANCER CHEMOPREVENTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
T. Narisawa e Y. Fukaura, "A VERY-LOW DOSE OF GREEN TEA POLYPHENOLS IN DRINKING-WATER PREVENTS N-METHYL-N-NITROSOUREA-INDUCED COLON CARCINOGENESIS IN F344 RATS", Japanese journal of cancer research, 84(10), 1993, pp. 1007-1009

Abstract

The effect of tea polyphenols, major constituents of tea, on colon carcinogenesis was investigated. A total of 129 female F344 rats were given an intrarectal instillation of 2 mg of N-methyl-N-nitrosourea 3 times a week for 2 weeks, and received a water solution of green tea extract (GTE) as drinking water throughout the experiment. Autopsies at week 35 revealed significantly lower incidence of colon carcinomas in rats ingesting 0.05%, 0.01% or 0.002% GTE solution than in controls ingesting 0% GTE solution: 43%, 40% and 33% vs. 67%. The data suggest that GTE, even at a very low dose (0.002% solution), has a potent inhibitory effect on colon carcinogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:01:26