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Titolo:
GAMMA-KNIFE SURGERY FOR SECRETING PITUITARY-ADENOMAS
Autore:
MORANGERAMOS I; REGIS J; DUFOUR H; ANDRIEU JM; GRISOLI F; JAQUET P; PERAGUT JC;
Indirizzi:
HOP LA TIMONE,DEPT ENDOCRINOL,264 RUE ST PIERRE F-13005 MARSEILLE FRANCE HOP LA TIMONE,DEPT NEUROSURG F-13005 MARSEILLE FRANCE
Titolo Testata:
Acta neurochirurgica
fascicolo: 5, volume: 140, anno: 1998,
pagine: 437 - 443
SICI:
0001-6268(1998)140:5<437:GSFSP>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
STEREOTAXIC RADIOSURGERY; CUSHINGS-DISEASE; IRRADIATION; RADIATION; GROWTH; TUMORS;
Keywords:
GAMMA-KNIFE; RADIOSURGERY; RADIOTHERAPY; PITUITARY ADENOMAS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
I. Morangeramos et al., "GAMMA-KNIFE SURGERY FOR SECRETING PITUITARY-ADENOMAS", Acta neurochirurgica, 140(5), 1998, pp. 437-443

Abstract

We report our preliminary results concerning 25 patients with secreting pituitary adenomas treated with stereotactic radiosurgery after partial transsphenoidal surgery and followed over a 6-36 month-period. Among the 15 acromegalic patients, a decrease of 65% in mean GH levels was achieved after 6 months and of 77% at 12 months after radiosurgery. Presently, only 3 patients (20%) are considered as in remission (meanGH and IGF1 level into the normal range). A decrease of 46% and 64% was observed at 6 and 12 months after radiosurgery in 4 patients with prolactinomas although no normalization of PRL levels occurred. Presently, 3/4 patients have individual PRL levels slightly above the normal range. A normalization of Urinary Free Cortisol(UFC) was noticed in 4/6 (66%) patients with Gushing's disease within 6-12 months. No pituitary deficiency was noticed in this series with the exception of 4/25 patients (16%) who received subtotal or total pituitary irradiation for post-operative remnants of secreting adenomas poorly defined on MRI. One woman, who had undergone previously a conventional irradiation and presenting with a cavernous sinus adenoma reaching the optic nerve, developed an optic neuropathy. A second woman, with a cavernous sinus remnant, presented a cranial nerve palsy (VI) after the irradiation. We can conclude that radiosurgery using the Cobalt-60 Gamma-unit is, at least, as effective as conventional radiotherapy in the control of pituitary hormone hypersecretion from postoperative adenomas remnants withless adverse effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 20:03:36