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Titolo:
HALOPERIDOL BLOCKS INCREASED LOCOMOTOR-ACTIVITY ELICITED BY CARBACHOLINFUSION INTO THE VENTRAL HIPPOCAMPAL-FORMATION
Autore:
BRENNER DM; BARDGETT ME;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT,MED SCH BOX 8134,4940 CHILDRENSPL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT ST LOUIS MO 63110
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 3, volume: 60, anno: 1998,
pagine: 759 - 764
SICI:
0091-3057(1998)60:3<759:HBILEB>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-ACCUMBENS; PREFRONTAL CORTEX; EXTRACELLULAR DOPAMINE; ANTEROGRADE TRANSPORT; RAT; PROJECTIONS; TERMINALS; SCHIZOPHRENIA; SUBICULUM; STRIATUM;
Keywords:
HIPPOCAMPUS; DOPAMINE; ANTIPSYCHOTIC; NUCLEUS ACCUMBENS; CAUDATE-PUTAMEN; PREFRONTAL CORTEX; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
D.M. Brenner e M.E. Bardgett, "HALOPERIDOL BLOCKS INCREASED LOCOMOTOR-ACTIVITY ELICITED BY CARBACHOLINFUSION INTO THE VENTRAL HIPPOCAMPAL-FORMATION", Pharmacology, biochemistry and behavior, 60(3), 1998, pp. 759-764

Abstract

Previous studies have demonstrated that stimulation of the ventral hippocampal (VH) formation (including the ventral CA1 and subicular areas) elicits increased locomotor activity in rats. The locomotor-activating effects of VH stimulation have been hypothesized to be mediated via hippocampal output to cortical and subcortical dopamine (DA) systems. This study examined whether increased locomotor activity produced byVH stimulation was blocked by pretreatment with a DA receptor antagonist, and whether DA metabolism in subdivisions of the nucleus accumbens, caudate-putamen, and prefrontal cortex was elevated by VH stimulation. Stimulation of the VH (defined as the ventral CA2 and its borders,ventral subiculum, and entorhinal cortex) with the cholinergic agonist carbachol was found to elevate locomotor activity, while pretreatment with the Dp receptor antagonist haloperidol blocked this effect. Stimulation of the VII did not alter DA metabolism (i.e., ratio of the DAmetabolites DOPAC or HVA/DA) in any of the brain regions studied. These results indicate that the increased locomotor activity elicited by VH stimulation is not associated with dramatic increases in DA metabolism, but that it does require tonic activation of D-2 receptors. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 15:03:59