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Titolo:
FIBROBLAST GROWTH FACTOR-2 (FGF-2) INDUCES VASCULAR ENDOTHELIAL GROWTH-FACTOR (VEGF) EXPRESSION IN THE ENDOTHELIAL-CELLS OF FORMING CAPILLARIES - AN AUTOCRINE MECHANISM CONTRIBUTING TO ANGIOGENESIS
Autore:
SEGHEZZI G; PATEL S; REN CJ; GUALANDRIS A; PINTUCCI G; ROBBINS ES; SHAPIRO RL; GALLOWAY AC; RIFKIN DB; MIGNATTI P;
Indirizzi:
NYU,MED CTR,DEPT CELL BIOL,550 1ST AVE NEW YORK NY 10016 NYU,MED CTR,DEPT CELL BIOL NEW YORK NY 10016 NYU,MED CTR,RAYMOND & BEVERLY SACKLER FDN LAB NEW YORK NY 10016 NYU,MED CTR,KAPLAN CANC CTR NEW YORK NY 10016 NYU,MED CTR,DEPT SURG NEW YORK NY 10016 NYU,MED CTR,CARDIOVASC SURG RES LAB NEW YORK NY 10016 NYU,MED CTR,SA LOCALIO GEN SURG RES LAB NEW YORK NY 10016
Titolo Testata:
The Journal of cell biology
fascicolo: 7, volume: 141, anno: 1998,
pagine: 1659 - 1673
SICI:
0021-9525(1998)141:7<1659:FGF(IV>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR GENE-EXPRESSION; SMOOTH-MUSCLE CELLS; SUBENDOTHELIAL EXTRACELLULAR-MATRIX; PLASMINOGEN-ACTIVATOR PRODUCTION; SECRETORY SIGNAL SEQUENCE; PERMEABILITY FACTOR; TUMOR ANGIOGENESIS; MOLECULAR-WEIGHT; IN-VIVO; DNA-SYNTHESIS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
107
Recensione:
Indirizzi per estratti:
Citazione:
G. Seghezzi et al., "FIBROBLAST GROWTH FACTOR-2 (FGF-2) INDUCES VASCULAR ENDOTHELIAL GROWTH-FACTOR (VEGF) EXPRESSION IN THE ENDOTHELIAL-CELLS OF FORMING CAPILLARIES - AN AUTOCRINE MECHANISM CONTRIBUTING TO ANGIOGENESIS", The Journal of cell biology, 141(7), 1998, pp. 1659-1673

Abstract

FGF-2 and VEGF are potent angiogenesis inducers in vivo and in vitro,Here we show that FGF-2 induces VEGF expression in vascular endothelial cells through autocrine and paracrine mechanisms. Addition of recombinant FGF-2 to cultured endothelial cells or upregulation of endogenous FGF-2 results in increased VEGF expression, Neutralizing monoclonalantibody to VEGF inhibits FGF-2-induced endothelial cell proliferation, Endogenous 18-kD FGF-2 production upregulates VEGF expression through extracellular interaction with cell membrane receptors; high-M-r FGF-2 (22-24-kD) acts via intracellular mechanism(s). During angiogenesis induced by FGF-2 in the mouse cornea, the endothelial cells of forming capillaries express VEGF mRNA and protein. Systemic administration of neutralizing VEGF antibody dramatically reduces FGF-2-induced angiogenesis. Because occasional fibroblasts or other cell types present inthe corneal stroma show no significant expression of VEGF mRNA, thesefindings demonstrate that endothelial cell-derived VEGF is an important autocrine mediator of FGF-2-induced angiogenesis, Thus, angiogenesis in vivo can be modulated by a novel mechanism that involves the autocrine action of vascular endothelial cell-derived FGF-2 and VEGF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:44:53