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Titolo:
ANGIOTENSIN-II RECEPTOR SUBTYPE AT(1) AND AT(2) EXPRESSION AFTER HEART-TRANSPLANTATION
Autore:
GULLESTAD L; HAYWOOD G; AASS H; ROSS H; YEE G; UELAND T; GEIRAN O; KJEKSHUS J; SIMONSEN S; BISHOPRIC N; FOWLER M;
Indirizzi:
STANFORD UNIV,SCH MED,FALK CARDIOVASC RES CTR,300 PASTEUR DR STANFORDCA 94305 STANFORD UNIV,SCH MED,FALK CARDIOVASC RES CTR STANFORD CA 94305 UNIV HOSP,RIKSHOSP OSLO NORWAY
Titolo Testata:
Cardiovascular Research
fascicolo: 2, volume: 38, anno: 1998,
pagine: 340 - 347
SICI:
0008-6363(1998)38:2<340:ARSAAA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-VENTRICULAR HYPERTROPHY; MESSENGER-RNA; CONVERTING ENZYME; GENE-EXPRESSION; CARDIAC MYOCYTES; TYPE-1 RECEPTOR; CELL-GROWTH; RAT; FAILURE; HYPERTENSION;
Keywords:
CLINICAL; HEART; MOLECULAR BIOLOGY; HUMAN; ANGIOTENSIN; GENE EXPRESSION; RECEPTORS; TRANSPLANTATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
L. Gullestad et al., "ANGIOTENSIN-II RECEPTOR SUBTYPE AT(1) AND AT(2) EXPRESSION AFTER HEART-TRANSPLANTATION", Cardiovascular Research, 38(2), 1998, pp. 340-347

Abstract

Objective: Cardiac hypertrophy appears early after heart transplantation, and may represent a myocardial response to injury. Recent evidence suggests that angiotensin II (Ang Ii) may promote growth through theAT(1) and inhibit growth through the AT(2) receptor subtypes. We therefore asked whether hypertrophy after heart transplantation is characterized by alterations in Ang II receptor gene expression. Methods: Theexpression of Ang II receptor subtypes, AT(1) and AT(2), was analyzedin right ventricular endomyocardial biopsies taken from 10 human donor hearts prior to implantation (controls) and from 17 heart transplantrecipients, Il studied during annual evaluation (> 1 year after transplantation) and 6 one week after transplantation. Competitive reverse transcription polymerase chain reaction (RT-PCR) was performed using synthetic RNA internal standards for both receptor subtypes. Results: AT(1) and AT(2) receptor mRNAs were detected in all samples. AT(1) receptor mRNA decreased 4.5 fold (p <0.01) and AT(2) receptor mRNA 4.2 fold (p < 0.001) in transplant patients compared with controls. In the subgroup of patients examined one week after surgery AT(1) was reduced relative to AT(2) receptor mRNA, resulting in an altered ratio of AT(1)to AT(2) early after transplantation, There was no correlation between Ang II receptor levels and left ventricular wall thickness, and the decrease in receptor level did not correlate with any hemodynamic parameters, cyclosporine blood levels, or plasma renin, Ang II or pANP, except for a negative correlation between AT(2) mRNA and plasma renin (r= - 0.49,p = 0.05). Conclusions: Contrary to our expectations, mRNA for both Ang II receptors was downregulated after heart transplantation. The cause of myocardial hypertrophy after heart transplantation is still unclear, but the hypertrophy does not appear to be driven by increased transcription of the AT(1) receptor. (C) 1998 Elsevier Science B. V. All fights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:42:31