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Titolo:
ANALYSIS OF FUS-CHOP FUSION TRANSCRIPTS IN DIFFERENT TYPES OF SOFT-TISSUE LIPOSARCOMA AND THEIR DIAGNOSTIC IMPLICATIONS
Autore:
WILLEKE F; RIDDER R; MECHTERSHEIMER G; SCHWARZBACH M; DUWE A; WEITZ J; LEHNERT T; HERFARTH C; DOEBERITZ MV;
Indirizzi:
UNIV HEIDELBERG,DEPT SURG,DIV MOL DIAGNOST & THERAPY,NEUENHEIMER FELD110 D-69120 HEIDELBERG GERMANY UNIV HEIDELBERG,INST PATHOL D-69120 HEIDELBERG GERMANY UNIV HEIDELBERG,DEPT SURG,DIV SURG ONCOL D-69120 HEIDELBERG GERMANY
Titolo Testata:
Clinical cancer research
fascicolo: 7, volume: 4, anno: 1998,
pagine: 1779 - 1784
SICI:
1078-0432(1998)4:7<1779:AOFFTI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; ROUND-CELL LIPOSARCOMA; RNA-BINDING PROTEIN; MYXOID LIPOSARCOMA; TUMOR-CELLS; GENE; EXPRESSION; EWS; TLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
F. Willeke et al., "ANALYSIS OF FUS-CHOP FUSION TRANSCRIPTS IN DIFFERENT TYPES OF SOFT-TISSUE LIPOSARCOMA AND THEIR DIAGNOSTIC IMPLICATIONS", Clinical cancer research, 4(7), 1998, pp. 1779-1784

Abstract

In myxoid and round cell liposarcomas, a specific chromosomal translocation [(12;16)(q13;p11)] results in the expression of chimeric fusiontranscripts encompassing parts of the FUS gene (16p11) at their 5' ends and the CHOP gene (12q13) at their 3' ends. Using a reverse transcription-PCR protocol, we determined the prevalence of FUS-CHOP fusion transcripts in a series of liposarcoma samples. Fusion transcripts weredetected in 13 of 30 biopsy samples from soft tissue liposarcomas. Expression of fusion transcripts was not restricted to myxoid and round cell liposarcomas, as suggested previously; it was also detected in 1 of 3 well-differentiated and 4 of 14 pleomorphic liposarcomas. Sequence analysis revealed four different FUS-CHOP fusion transcript variants, two of which have not been described before. Furthermore, using FUS-CHOP fusion transcripts as targets in reverse transcription-PCR assays, we detected disseminated tumor cells in peripheral blood or bone marrow in 3 of 5 patients undergoing surgery for soft tissue liposarcoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 01:03:16