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Titolo:
DOWN-REGULATION OF FAS-ASSOCIATED PHOSPHATASE-1 (FAP-1) IN INTERLEUKIN-2-ACTIVATED T-CELLS
Autore:
ZHOU YW; KOMADA Y; INABA H; AZUMA E; SAKURA M;
Indirizzi:
MIE UNIV,SCH MED,DEPT PEDIAT,2-174 EDOBASHI TSU MIE 514 JAPAN MIE UNIV,SCH MED,DEPT CLIN IMMUNOL TSU MIE 514 JAPAN
Titolo Testata:
Cellular immunology (Print)
fascicolo: 2, volume: 186, anno: 1998,
pagine: 103 - 110
SICI:
0008-8749(1998)186:2<103:DOFP(I>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; MEDIATED APOPTOSIS; LYMPHOPROLIFERATIVE SYNDROME; DIFFERENTIAL EXPRESSION; PERIPHERAL-BLOOD; CD95 FAS/APO-1; DEATH DOMAIN; ACTIVATION; LIGAND; ANTIGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
Y.W. Zhou et al., "DOWN-REGULATION OF FAS-ASSOCIATED PHOSPHATASE-1 (FAP-1) IN INTERLEUKIN-2-ACTIVATED T-CELLS", Cellular immunology (Print), 186(2), 1998, pp. 103-110

Abstract

Peripheral T cells are resistant to Pas receptor (FasR/CD95)-mediatedapoptosis. After prolonged treatment with interleukin-2 (IL-2), theseT cells develop a Fas-sensitive phenotype. To clarify the molecular mechanism of apoptosis susceptibility, mRNA expression of FasR-associated proteins [Fas-associating protein with death domain (FADD), receptor-interacting protein (RIP), and Pas-associated phosphatase-1 (FAP-1)]has been investigated in IL-2-activated T cells. Competitive reverse transcriptase-polymerase chain reaction analysis revealed that FADD and RIP mRNA were equally expressed in freshly isolated resting T cells and IL-2-activated T cells. In contrast, FAP-1 mRNA was produced more abundantly by Fas-resistant resting T cells than by Fas-sensitive activated T cells. These findings suggested that sensitivity to FasR-mediated apoptosis in T cells could be correlated with down-regulation of FAP-1 expression. Additionally, CD45RO(+) memory T cells expressed a larger amount of FAP-1 mRNA than did CD45RA(+) naive T cells. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 02:02:49