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Titolo:
XENOPUS CRMP-2 IS AN EARLY RESPONSE GENE TO NEURAL INDUCTION
Autore:
KAMATA T; DAAR IO; SUBLESKI M; COPELAND T; KUNG HF; XU RH;
Indirizzi:
NCI,LAB BIOCHEM PHYSIOL,FCRDC,BLDG 567,RM 152 FREDERICK MD 21702 NCI,IRSP,SAIC,FCRDC FREDERICK MD 21702 NCI,LLB,DBS,FCRDC FREDERICK MD 21702 NCI,ABL BASIC RES PROGRAM,FCRDC FREDERICK MD 21702 NCI,LBP,DBS,FCRDC FREDERICK MD 21702
Titolo Testata:
Molecular brain research
fascicolo: 2, volume: 57, anno: 1998,
pagine: 201 - 210
SICI:
0169-328X(1998)57:2<201:XCIAER>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE MORPHOGENETIC PROTEIN-4; AXONAL GUIDANCE; SPINAL-CORD; VENTRALIZING FACTOR; ADHESION MOLECULES; UNC-33; SIGNALS; FAMILY; COLLAPSIN; OUTGROWTH;
Keywords:
XENOPUS; XCRMP-2 GENE; NEURAL INDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
T. Kamata et al., "XENOPUS CRMP-2 IS AN EARLY RESPONSE GENE TO NEURAL INDUCTION", Molecular brain research, 57(2), 1998, pp. 201-210

Abstract

A neural specific protein, CRMP-2 (for Collapsin Response Mediator Protein-2), is considered to mediate collapsin-induced growth cone collapse during neural development. We have isolated the Xenopus homologue of the CRMP-2 (XCRMP-2) cDNA and studied the expression of XCRMP-2 mRNA and protein during neural induction. Induction of XCRMP-2 mRNA and protein expression, like N-CAM, occurred at the midgastrula stage and increased through early neural developmental stages. Whole mount in situ hybridization demonstrated that expression of XCRMP-2 mRNA was localized in neural tissues such as the neural plate and tube at early stages, while its expression in the brain, spinal cord, and eyes was observed at later stages. Immunostaining of Xenopus embryos with the antibody against CRMP-2 also showed that the protein was specifically expressed in the neural tissues at early stages. XCRMP-2 expression was induced by neural inducers such as noggin and chordin which antagonize a neural inhibitor, BMP4. A dominant negative BMP receptor also induced XCRMP-2 expression, suggesting that transcription of XCRMP-2 gene was negatively regulated by the BMP4 signaling. These results indicate thatexpression of XCRMP-2 is an early response marking neural commitment,and that transcriptional control of XCRMP-2 gene, is one of the targets of BMP4 signaling. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/02/20 alle ore 20:38:47