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Titolo:
EFFECTS OF THE GABAERGIC SYSTEM ON IN-VIVO BINDING OF [H-3]N-METHYLSPIPERONE
Autore:
NAKANO T; KOBAYASHI K; HOSOI R; WAKAHARA S; WATANABE Y; NISHIMURA T; INOUE O;
Indirizzi:
OSAKA UNIV,FAC MED,SCH ALLIED HLTH SCI,DEPT RADIOL TECHNOL & BIOL ENGN,DIV MED PHYS SUITA OSAKA 5650871 JAPAN OSAKA UNIV,FAC MED,SCH ALLIED HLTH SCI,DEPT RADIOL TECHNOL & BIOL ENGN,DIV MED PHYS SUITA OSAKA 5650871 JAPAN OSAKA UNIV,SCH MED,CTR BIOMED RES,DIV TRACER KINET SUITA OSAKA 5650871 JAPAN SCI UNIV TOKYO,FAC PHARMACEUT SCI,DEPT RADIOPHARM,SHINJUKU KU TOKYO 1620826 JAPAN OSAKA BIOSCI INST,DEPT NEUROSCI SUITA OSAKA 5650874 JAPAN JAPAN SCI & TECHNOL CORP,SUBFEMTOMOLE BIORECOGNIT PROJECT SUITA OSAKA5650082 JAPAN
Titolo Testata:
Neuropharmacology
fascicolo: 3, volume: 37, anno: 1998,
pagine: 375 - 381
SICI:
0028-3908(1998)37:3<375:EOTGSO>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; H-3 N-METHYLSPIPERONE; BRAIN BENZODIAZEPINE RECEPTORS; TIME UPTAKE DATA; INVIVO BINDING; ENDOGENOUS DOPAMINE; GRAPHICAL EVALUATION; SEROTONIN RECEPTORS; LIPID-PEROXIDATION; TRANSFER CONSTANTS;
Keywords:
DOPAMINE; N-METHYLSPIPERONE; GABAERGIC SYSTEM; FLUNITRAZEPAM; IN VIVO; NEURONAL INTERACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
T. Nakano et al., "EFFECTS OF THE GABAERGIC SYSTEM ON IN-VIVO BINDING OF [H-3]N-METHYLSPIPERONE", Neuropharmacology, 37(3), 1998, pp. 375-381

Abstract

The effects of flunitrazepam, a benzodiazepine receptor agonist and those of NNC-711, a GABA transporter blocker, on the in vivo binding of[H-3]N-methylspiperone: a dopamine D-2 receptor antagonist: were investigated in mouse brain. Treatment with either flunitrazepam or NNC-711 reduced the specific binding of [H-3]N-methylspiperone in the striatum. Flumazenil, a central benzodiazepine receptor antagonist, blocked the effect of flunitrazepam, indicating that the reduction in specificbinding in the striatum was mediated via the GABAergic system. The flunitrazepam significantly decreased the specific binding of [H-3]N-methylspiperone in the striatum at all time points studied after tracer injection, whereas specific binding in the cerebellum and cerebral cortex was unaltered. This decrease in specific binding in the striatum was found to be due to a reduced input rate constant (k(3)) of [H-3]N-methylspiperone. The maximum number of the binding sites available for dopamine D-2 receptors in the striatum was not changed by the flunitrazepam treatment. (C) 1998 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 01:05:39