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Titolo:
THE EFFECTS OF ACUTE AND REPEATED COCAINE INJECTIONS ON PROTEIN-KINASE-C ACTIVITY AND ISOFORM LEVELS IN DOPAMINERGIC BRAIN-REGIONS
Autore:
STEKETEE JD; ROWE LA; CHANDLER LJ;
Indirizzi:
LOUISIANA STATE UNIV,MED CTR,DEPT PHARMACOL & THERAPEUT,1501 KINGS HIGHWAY SHREVEPORT LA 71130
Titolo Testata:
Neuropharmacology
fascicolo: 3, volume: 37, anno: 1998,
pagine: 339 - 347
SICI:
0028-3908(1998)37:3<339:TEOAAR>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; HIPPOCAMPAL-KINDLED RAT; BEHAVIORAL SENSITIZATION; TIME-COURSE; EXTRACELLULAR DOPAMINE; INCREASE; ADAPTATIONS; EXPRESSION; ADDICTION; RESPONSES;
Keywords:
BEHAVIORAL SENSITIZATION; COCAINE; MEDIAL PREFRONTAL CORTEX; NUCLEUS ACCUMBENS; PROTEIN KINASE C; STRIATUM; SUBSTANTIA NIGRA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
J.D. Steketee et al., "THE EFFECTS OF ACUTE AND REPEATED COCAINE INJECTIONS ON PROTEIN-KINASE-C ACTIVITY AND ISOFORM LEVELS IN DOPAMINERGIC BRAIN-REGIONS", Neuropharmacology, 37(3), 1998, pp. 339-347

Abstract

The present study was designed to assess the effects of acute and repeated cocaine exposure on protein kinase C (PKC) activity and the levels of calcium-dependent isoforms of PKC in mesocorticolimbic and nigrostriatal dopamine brain regions. Animals received repeated injections of saline or cocaine and were challenged with saline or cocaine 24 h or 7 days after the last of their daily injections. Animals were sacrificed 2, 6 or 24 h after the challenge injection and their brains were dissected and used in PKC studies. The data demonstrated that previously reported cocaine-induced increases in PKC activity in the ventral tegmental area are transient and not associated with changes in the levels of calcium-dependent isoforms of PKC. In addition, there was a decrease in membrane-associated PKC activity, with a concomitant increasein the levels of PKC beta(1) in the medial prefrontal cortex 24 h after the last injection of cocaine. These data suggest that changes in PKC activity in the ventral tegmental area may be involved in the initiation of sensitization whereas changes in PKC: activity in the medial prefrontal cortex may be related to the expression of the sensitized response to cocaine. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 09:49:56