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Titolo:
MODIFICATION OF BEHAVIORAL-RESPONSES INDUCED BY ELECTRICAL-STIMULATION OF THE VENTRAL TEGMENTAL AREA IN RATS
Autore:
WATANABE T; MORIMOTO K; NAKAMURA M; SUWAKI H;
Indirizzi:
KAGAWA MED UNIV,FAC MED,DEPT NEUROPSYCHIAT KAGAWA 76107 JAPAN
Titolo Testata:
Behavioural brain research
fascicolo: 1-2, volume: 93, anno: 1998,
pagine: 119 - 129
SICI:
0166-4328(1998)93:1-2<119:MOBIBE>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED LOCOMOTOR-ACTIVITY; NIGRA PARS RETICULATA; A10 DOPAMINE NEURONS; NUCLEUS-ACCUMBENS; PREFRONTAL CORTEX; D-AMPHETAMINE; RECEPTOR AGONISTS; LASTING INCREASE; SENSITIZES RATS; DAILY COCAINE;
Keywords:
VENTRAL TEGMENTAL AREA; MESOLIMBIC DOPAMINE PATHWAY; ELECTRICAL STIMULATION; METHAMPHETAMINE; BEHAVIORAL SENSITIZATION; PSYCHOSIS MODEL; NUCLEUS ACCUMBENS; PREFRONTAL CORTEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
T. Watanabe et al., "MODIFICATION OF BEHAVIORAL-RESPONSES INDUCED BY ELECTRICAL-STIMULATION OF THE VENTRAL TEGMENTAL AREA IN RATS", Behavioural brain research, 93(1-2), 1998, pp. 119-129

Abstract

To investigate the role of the ventral tegmental area (VTA), a sourceof the mesolimbic dopaminergic pathway, in paranoid psychosis, a detailed analysis of the behavioral responses induced by electrical stimulation of the VTA was made. Abnormal behavior induced by bilateral high-frequency stimulation of the VTA consisted of two components: forwardlocomotion and exploration. Similar responses were obtained when the nucleus accumbens (NAC) or prefrontal cortex (PFC) were stimulated. The expression of behavioral responses to stimulation was significantly attenuated by dopamine (DA) receptor or antagonists, such as haloperidol, YM-09151-2 and SCH2339Q. These results indicate that VTA stimulation causes a transient hyperdopaminergic state in the brain, that resembles psychostimulant-induced abnormal behavior. The effects of chronicadministration of methamphetamine (MAP) on the behavioral responses to electrical stimulation of the VAT were also investigated. Although an acute administration of MAP did not affect the behavioral responses to electrical stimulation of the VTA, chronic treatment with MAP (for 2 weeks) caused a long-lasting reduction in the electrical threshold for the induction of abnormal behavior, compared with chronic saline-treated rats. It is suggested that a lasting enhancement in the behavioral response to stimulation of VTA neurons may contribute to the etiology of paranoid schizophrenia and amphetamine psychosis. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 10:39:37