Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
COCAINE DECREASES CORTICAL CEREBRAL BLOOD-FLOW BUT DOES NOT OBSCURE REGIONAL ACTIVATION IN FUNCTIONAL MAGNETIC-RESONANCE-IMAGING IN HUMAN-SUBJECTS
Autore:
GOLLUB RL; BREITER HC; KANTOR H; KENNEDY G; GASTFRIEND D; MATHEW RT; MAKRIS N; GUIMARAES A; RIORDAN J; CAMPBELL T; FOLEY M; HYMAN SE; ROSEN B; WEISSKOFF R;
Indirizzi:
MASSACHUSETTS GEN HOSP,CNY 9109,149 13TH ST CHARLESTOWN MA 02129 MASSACHUSETTS GEN HOSP,DEPT PSYCHIAT BOSTON MA 02114 MASSACHUSETTS GEN HOSP,DEPT RADIOL,NUCL MAGNET RESONANCE CTR BOSTON MA 02114 MASSACHUSETTS GEN HOSP,DEPT CARDIOL BOSTON MA 02114 HARVARD UNIV,SCH MED BOSTON MA 00000 MASSACHUSETTS GEN HOSP,CTR MORPHOMETR ANAL BOSTON MA 02114
Titolo Testata:
Journal of cerebral blood flow and metabolism
fascicolo: 7, volume: 18, anno: 1998,
pagine: 724 - 734
SICI:
0271-678X(1998)18:7<724:CDCCBB>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; HUMAN BRAIN; SENSORY STIMULATION; ACUTE TOLERANCE; METABOLISM; AREAS;
Keywords:
CEREBRAL BLOOD FLOW (CBF); FUNCTIONAL MAGNETIC RESONANCE IMAGING (FMRI); NEUROIMAGING; PSYCHOSTIMULANTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
R.L. Gollub et al., "COCAINE DECREASES CORTICAL CEREBRAL BLOOD-FLOW BUT DOES NOT OBSCURE REGIONAL ACTIVATION IN FUNCTIONAL MAGNETIC-RESONANCE-IMAGING IN HUMAN-SUBJECTS", Journal of cerebral blood flow and metabolism, 18(7), 1998, pp. 724-734

Abstract

The authors used functional magnetic resonance imaging (fMRI) to determine whether acute intravenous (IV) cocaine use would change global cerebral blood flow (CBF) or visual stimulation-induced functional activation. They used flow-sensitive alternating inversion recovery (FAIR)scan sequences to measure CBF and blood oxygen level-dependent (BOLD)sensitive T-2 scan sequences during visual stimulation to measure neuronal activation before and after cocaine and saline infusions. Cocaine (0.6 mg/kg IV over 30 seconds) increased heart rate and mean blood pressure and decreased end tidal carbon dioxide (CO2). All measures returned to baseline by 2 hours, the interinfusion interval, and were unchanged by saline. Flow-sensitive alternating inversion recovery imaging demonstrated that cortical gray matter CBF was unchanged after saline infusion (-2.4 +/- 6.5%) but decreased (-14.1 +/- 8.5%) after cocaine infusion (n = 8, P < 0.01). No decreases were detected in white matter, nor were changes found comparing BOLD signal intensity in cortical gray matter immediately before cocaine infusion with that measured 10 minutes after infusion. Visual stimulation resulted in comparable BOLD signal increases in visual cortex in all conditions (before and after cocaine and saline infusion). Despite a small (14%) but significantdecrease in global cortical gray matter CBF after acute cocaine infusion, specific regional increases in BOLD imaging, mediated by neurons,can be measured reliably.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:21:32