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Titolo:
EXPRESSION OF GAMMA-IFN RESPONSIVE GENES IN SCAVENGER RECEPTOR OVER-EXPRESSING MONOCYTES IS ASSOCIATED WITH XANTHOMATOSIS
Autore:
GREWAL T; BOUDREAU M; ROY M; CHAMBERLAND A; LEFEBVRE C; LAVIGNE J; DAVIGNON J; MINNICH A;
Indirizzi:
CLIN RES INST MONTREAL,HYPERLIPIDEMIA & ATHEROSCLEROSIS RES GRP,110 PINE AVE W MONTREAL PQ H2W 1R7 CANADA UNIV HAMBURG,KRANKENHAUS EPPENDORF,MED KLIN,BIOCHEM STOFFWECHSELLABORD-20246 HAMBURG GERMANY RHONE POULENC RORER,RES & DEV COLLEGEVILLE PA 19426
Titolo Testata:
Atherosclerosis (Amsterdam)
fascicolo: 2, volume: 138, anno: 1998,
pagine: 335 - 345
SICI:
0021-9150(1998)138:2<335:EOGRGI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY LIPOPROTEIN; INTERFERON-INDUCIBLE PROTEIN-10; FOAM CELLS; CHOLESTEROL DEPOSITION; MACROPHAGES; ATHEROSCLEROSIS; DEGRADATION; HYPERCHOLESTEROLEMIA; CHEMOATTRACTANT; TRANSCRIPTION;
Keywords:
STAT1-ALPHA; IP-10; GAMMA-INTERFERON; SCAVENGER RECEPTOR; MACROPHAGE ACTIVATION; FOAM CELL; XANTHOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
T. Grewal et al., "EXPRESSION OF GAMMA-IFN RESPONSIVE GENES IN SCAVENGER RECEPTOR OVER-EXPRESSING MONOCYTES IS ASSOCIATED WITH XANTHOMATOSIS", Atherosclerosis (Amsterdam), 138(2), 1998, pp. 335-345

Abstract

We have recently described an inherited over-expression of the macrophage scavenger receptor (SR) in blood monocytes from members of a kindred, only two of whom displayed extensive xanthomatosis. Using mRNA differential display we demonstrated abnormally high expression of the signal transducer and activator of transcription (STAT1 alpha) in monocytes from the proband II-2. Expression of gamma-interferon inducible protein 10 (IP-10), a STAT1 alpha-responsive gene and mediator of inflammatory response, was also abnormally expressed in the monocytes from II-2. Over-expression of both genes was restricted to monocytes from II-2 and was not observed in monocytes from the clinically unaffected family members, unlike that of SR. Gel retardation assays with THP-1 cell extracts identified gamma-IFN inducible DNA binding activity to three potential STAT1 DNA binding elements in the human IP-10 promoter region from nucleotides -245 to -188. Taken together these results suggest that gamma-interferon mediated cell activation is responsible for STAT1 alpha-induced transcription of the IP-10 gene in THP-I macrophages as well as in monocytes from II-2. Analysis of monocytes from familial hypercholesterolemic (FH) subjects, who frequently develop xanthomatosis, revealed a significant number of subjects with elevated STAT1 alpha and IP-10 expression. Our data suggest that the inflammatory effects of gamma-IFN signaling could play a role in foam cell formation and xanthomatosis. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:46:08