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Titolo:
CONTRIBUTION OF THE GLYCINE SITE OF NMDA RECEPTORS IN ROSTRAL AND INTERMEDIATE-CAUDAL PARTS OF THE STRIATUM TO THE REGULATION OF MUSCLE TONE IN RATS
Autore:
LORENCKOCI E; KONIECZNY J; WOLFARTH S;
Indirizzi:
POLISH ACAD SCI,INST PHARMACOL,DEPT NEUROPSYCHOPHARMACOL,12 SMETNA STPL-31343 KRAKOW POLAND
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 793, anno: 1998,
pagine: 315 - 320
SICI:
0006-8993(1998)793:1-2<315:COTGSO>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
HALOPERIDOL-INDUCED CATALEPSY; PARKINSONS-DISEASE; ANTAGONIST; RIGIDITY; MK-801; REFLEX;
Keywords:
NMDA RECEPTOR GLYCINE SITE; 5,7-DCKA; STRIATUM; MUSCLE RIGIDITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
E. Lorenckoci et al., "CONTRIBUTION OF THE GLYCINE SITE OF NMDA RECEPTORS IN ROSTRAL AND INTERMEDIATE-CAUDAL PARTS OF THE STRIATUM TO THE REGULATION OF MUSCLE TONE IN RATS", Brain research, 793(1-2), 1998, pp. 315-320

Abstract

The aim of the present study was to assess the contribution of the glycine site of NMDA receptors in the striatum to the regulation of muscle tone. Muscle tone was examined using a combined mechano and electromyographic method, which measured simultaneously the muscle resistance(MMG) of the rat's hind foot to passive extension and flexion in the ankle joint and the electromyographic activity (EMG) of the antagonistic muscles of that joint: gastrocnemius and tibialis anterior. Muscle rigidity was induced by haloperidol (2.5 mg/kg i.p.). 5,7-dichlorokynurenic acid (5,7-DCKA), a selective glycine site antagonist, injected in doses of 2.5 and 4.5 mu g/0.5 mu l bilaterally, into the rostral region of the striatum, decreased both the haloperidol-induced muscle rigidity (MMG) and the enhanced electromyographic activity (EMG). 5,7-DCKA injected bilaterally in a dose of 4.5 mu g/0.5 mu l into the intermediate-caudal region of the striatum of rats not pretreated with haloperidol had no effect on the muscle tone. The present results suggest that blockade of the glycine site of NMDA receptors in the rostral part of the striatum may be mainly responsible for the antiparkinsonian action of this drug. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 05:34:47