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Titolo:
SPATIAL AND TEMPORAL EVOLUTION OF NEURONAL ACTIVATION, STRESS AND INJURY IN LITHIUM-PILOCARPINE SEIZURES IN ADULT RATS
Autore:
MOTTE J; FERNANDES MJD; BARAM TZ; NEHLIG A;
Indirizzi:
FAC MED STRASBOURG,INSERM,U398,11 RUE HUMANN F-67085 STRASBOURG FRANCE FAC MED STRASBOURG,INSERM,U398 F-67085 STRASBOURG FRANCE CHU REIMS,AMER MEM HOSP REIMS FRANCE UCI,DEPT PEDIAT IRVINE CA 92697 UCI,DEPT ANAT & NEUROBIOL IRVINE CA 92697
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 793, anno: 1998,
pagine: 61 - 72
SICI:
0006-8993(1998)793:1-2<61:SATEON>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEAT-SHOCK PROTEIN; INDUCED STATUS EPILEPTICUS; MUSCARINIC CHOLINERGIC RECEPTORS; LIMBIC SEIZURES; KAINIC ACID; C-FOS; BRAIN-DAMAGE; TREATED RATS; EXPRESSION; HIPPOCAMPUS;
Keywords:
LIMBIC SEIZURE; LITHIUM-PILOCARPINE; FOS PROTEIN; HSP72; STRESS RESPONSE; NEURONAL DAMAGE; 2-DEOXYGLUCOSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
J. Motte et al., "SPATIAL AND TEMPORAL EVOLUTION OF NEURONAL ACTIVATION, STRESS AND INJURY IN LITHIUM-PILOCARPINE SEIZURES IN ADULT RATS", Brain research, 793(1-2), 1998, pp. 61-72

Abstract

In order to follow the spatial and temporal evolution of neuronal damage, cellular activation and stress responses subsequent to lithium-pilocarpine seizures of various durations in the adult rat, we analyzed the expression of Fos protein and local cerebral glucose utilization as markers of cellular activation, HSP72 immunoreactivity and acid fuchsin staining as indicators of cellular stress and injury, and Cresyl violet staining for the assessment of neuronal damage. The expression of Fos appeared very early, 2-30 min after the onset of polyspikes and intensified during the following 4 h. Fos immunoreactivity was especially high in the hippocampus, cerebral cortex, amygdala and anterior olfactory nuclei. Local cerebral glucose utilization measured during thesecond hour of seizures was largely increased (350-580%) over controllevels in cortical areas, amygdala, dentate gyrus, caudate nucleus and mediodorsal thalamus. HSP72 immunoreactivity never appeared earlier than 40-50 min after the onset of polyspikes, and was most prominent in hippocampal CA3 area, cerebral cortex (except the piriform cortex) and anterior olfactory nuclei. Acid fuchsin staining was maximal in thepiriform cortex and the polymorphic layer of the dentate gyrus. Staining was moderate in the sensorimotor cortex and the amygdala. Neuronaldamage was extensive in the piriform. and entorhinal cortices, the hippocampal CA3 area and the polymorphic layer of the dentate gyrus, basal amygdala, mediodorsal thalamus and anterior olfactory nuclei. In conclusion, the present study shows that brain regions with the highest expression of Fos and the largest metabolic activation were also highly stained with acid fuchsin and most heavily damaged. Conversely, there is no clear relationship between HSP72 expression, cellular activation and neuronal damage. (C) 1998 Elsevier Science B.V. All rights reserved.

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Documento generato il 10/07/20 alle ore 12:50:33