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Titolo:
EXPRESSION PATTERN OF THE ETS-RELATED TRANSCRIPTION FACTOR ELF-1
Autore:
BASSUK AG; BARTON KP; ANANDAPPA RT; LU MM; LEIDEN JM;
Indirizzi:
UNIV CHICAGO,DEPT MED,5841 S MARYLAND AVE CHICAGO IL 60637 UNIV CHICAGO,DEPT MED CHICAGO IL 60637 UNIV CHICAGO,DEPT PATHOL CHICAGO IL 60637
Titolo Testata:
Molecular medicine (Cambridge, Mass.)
fascicolo: 6, volume: 4, anno: 1998,
pagine: 392 - 401
SICI:
1076-1551(1998)4:6<392:EPOTET>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA-BINDING MOTIF; VIRUS TYPE-2 ENHANCER; T-CELLS; COOPERATIVE BINDING; REGULATORY ELEMENTS; DOMAIN PROTEIN; GENE; DROSOPHILA; COMPLEX; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
A.G. Bassuk et al., "EXPRESSION PATTERN OF THE ETS-RELATED TRANSCRIPTION FACTOR ELF-1", Molecular medicine (Cambridge, Mass.), 4(6), 1998, pp. 392-401

Abstract

Members of the Ets family of winged helix-loop-helix transcription factors play important roles in the development and function of multiplemammalian cell lineages. Elf-1 is an Ets-related transcription factorthat is expressed at high levels in T cells and is known to regulate the expression of several T cell genes, including the,granulocyte-macrophage colony stimulating factor (GMCSF) gene, the interleukin-2 receptor alpha subunit (IL-2R alpha) gene, and the CD4gene. In the studies described in this report, we have characterized the pattern of expression of Elf-1 in the developing mouse embryo and in adult mouse tissuesas well as in multiple immortalized human and murine cell lines. Elf-1 is expressed at high levels throughout thymocyte development, with equivalent levels of Elf-1 expression seen in all subsets of maturing thymocytes and T cells. Somewhat surprisingly, however, Elf-1 is also expressed at high levels in epithelial cells lining the oral cavity, the lung, the CNS, and the gastrointestinal and urinary tracts as well as in the skin of the developing mouse embryo and at lower levels in the adult mouse testis and liver. Western blot analyses of a large number of immortalized cell lines demonstrated high-level Elf-1 expression in T and B lymphocyte and macrophage cell lines as well as in two prostate carcinoma cell lines. Low-level expression was observed in fibroblasts, embryonic stem cells, and myoblasts. Taken together, our data suggest that in addition to its role in regulating T cell development and function, Elf-1 may regulate gene expression in the B cell and myelomonocytic lineages, as well as in multiple epithelial cell types during murine embryonic development.

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Documento generato il 23/09/20 alle ore 21:56:27