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Titolo:
WHAT HAVE SNAKES TAUGHT US ABOUT INTEGRINS
Autore:
HUANG TF;
Indirizzi:
NATL TAIWAN UNIV,COLL MED,INST PHARMACOL,1 JEN AI RD,1ST SEC TAIPEI TAIWAN
Titolo Testata:
Cellular and molecular life sciences
fascicolo: 6, volume: 54, anno: 1998,
pagine: 527 - 540
SICI:
1420-682X(1998)54:6<527:WHSTUA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLATELET-AGGREGATION INHIBITOR; ARG-GLY-ASP; GLYCOPROTEIN-IIB-IIIA; RGD-CONTAINING PEPTIDE; METALLOPROTEASE-DISINTEGRIN PROTEIN; WESTERN DIAMONDBACK RATTLESNAKE; NATURALLY-OCCURRING ANTAGONISTS; FIBRINOGEN RECEPTOR ANTAGONIST; CALLOSELASMA-RHODOSTOMA VENOM; VONWILLEBRAND-FACTOR BINDING;
Keywords:
SNAKE VENOM DISINTEGRIN; METALLOPROTEASE; ADAMS; INTEGRIN ALPHA(IIB)BETA(3), ALPHA(2)BETA(1), ALPHA(V)BETA(3); PLATELET AGGREGATION; HEMORRHAGE; CELL-MATRIX INTERACTION; CELL FUSION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
154
Recensione:
Indirizzi per estratti:
Citazione:
T.F. Huang, "WHAT HAVE SNAKES TAUGHT US ABOUT INTEGRINS", Cellular and molecular life sciences, 54(6), 1998, pp. 527-540

Abstract

Snake venoms contain unique components that affect cell-matrix interactions. Disintegrins represent a class of low molecular weight, Arg-Gly-Asp (RGD)containing, cysteine-rich peptides purified from the venom of various snakes among the Viperidae and Crotalidae. They bind with various degrees of specificity to integrins alpha(IIb)beta(3), alpha(5)beta(1) and alpha(V)beta(3) expressed on cells. Snake venom metalloproteases thigh molecular mass haemorrhagins) also contain disintegrin-like domains, in addition to zinc-chelating sequences. Membrane-anchoredADAMs (A Disintegrin And Metalloprotease domain), multidomain molecules consisting of metalloprotease, disintegrin-like, cysteine-rich, andepidermal growth factor domains, a transmembrane domain and a cytoplasmic tail, are a new family of proteins. In the light of the large number and wide distribution of ADAMs, they may participate in cell-cell fusion events, including sperm-egg binding and fusion, myoblast fusionand other cell-cell and cell-matrix interactions. The structure-function relationship of these molecules is discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 12:56:04