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Titolo:
EFFECTS OF GAMMA-RADIATION ON SNAKE-VENOMS
Autore:
NASCIMENTO N; SPENCER PJ; ANDRADE HF; GUARNIERI MC; ROGERO JR;
Indirizzi:
CNEN,IPEN,DIV RADIOBIOL,POB 11049 BR-05508900 SAO PAULO BRAZIL UNIV SAO PAULO,FAC MED,INST TROP MED BR-05508 SAO PAULO BRAZIL
Titolo Testata:
Radiation physics and chemistry (1993)
fascicolo: 1-6, volume: 52, anno: 1998,
pagine: 665 - 669
SICI:
0969-806X(1998)52:1-6<665:EOGOS>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Keywords:
CROTOXIN; GAMMA RADIATION; BIODISTRIBUTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
N. Nascimento et al., "EFFECTS OF GAMMA-RADIATION ON SNAKE-VENOMS", Radiation physics and chemistry (1993), 52(1-6), 1998, pp. 665-669

Abstract

Ionizing radiation is able to detoxify several venoms, including snake venoms, without affecting significantly their immunogenic properties. Inn order to elucidate this phenomena, we conceived a comparative pharmacological study between native and irradiated (2,000 Gy) crotoxin,the main toxin of the South American rattlesnake Crotalus durissus terrificus. Crotoxin was isolated and purified by molecular exclusion chromatography, pi precipitation and, susbequentely submitted to irradiation. Gel filtration of the irradiated toxin resulted in some high molecular weight aggregates formation. Crotoxin toxicity decreased two folds after irradiation, as determined by LD50 in mice. Native and irradiated crotoxin biodistribution ocured in the same general manner, withrenal elimination. However, in contrast to irradiated crotoxin, the native form was initially retained in kidneys. A later concentration (2-3 hr) appeared in phagocytic mononuclear cells rich organs (liver andspleen) and neural junction rich organs (muscle and brain).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 10:12:33