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Titolo:
THYMIC STROMAL CELLS PRODUCE SOLUBLE FACTORS WHICH INCREASE POLARIZATION OF CHICKEN THYMOCYTES
Autore:
MUKAMOTO M; KODAMA H; BABA T;
Indirizzi:
UNIV OSAKA PREFECTURE,COLL AGR,DEPT VET SCI,LAB VET IMMUNOL,1-1 GAKUEN CHO SAKAI OSAKA 593 JAPAN
Titolo Testata:
Avian pathology
fascicolo: 3, volume: 27, anno: 1998,
pagine: 284 - 289
SICI:
0307-9457(1998)27:3<284:TSCPSF>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHEMOTACTIC FACTORS; HUMAN-LYMPHOCYTES; T-CELLS; MIGRATION; IDENTIFICATION; SUBPOPULATIONS; GROWTH; EXPRESSION; RESPONSES; INDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
M. Mukamoto et al., "THYMIC STROMAL CELLS PRODUCE SOLUBLE FACTORS WHICH INCREASE POLARIZATION OF CHICKEN THYMOCYTES", Avian pathology, 27(3), 1998, pp. 284-289

Abstract

The effects were examined of soluble factors present in culture supernatant (CS) of thymic stromal cells (TSC) on the differentiation and locomotor activity of chicken thymocytes. The locomotor activity of thymocytes was assessed by Cell polarization assay. When thymocytes were incubated in the presence of TSC-CS, the proportion of polarized cellsincreased. This indicates that thymocytes acquired a potent locomotoractivity. A high proportion of peanut agglutinin-positive (PNA+) thymocytes, as well as CD4(-)CD8(-) and CD4(+)CD8(+) thymocytes showed polarization in TSC-CS. Bone marrow cells exhibited higher level of polarizing activity compared to CD4(+)CD8(-) and CD4(-)CD8(+) thymocytes and spleen T cells. These results suggest that thymic stromal cells secrete a soluble factor(s) which enhances mobilizing activity of immatureT cells. The factor may take part in the intrathymic migration of progenitor T cells into the site of differentiation.

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Documento generato il 17/01/21 alle ore 16:05:24