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Titolo:
72-KDA AND 92-KDA GELATINASES IN SALIVA OF PATIENTS WITH HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION
Autore:
MELLANEN L; SALO T; INGMAN T; KONTTINEN YT; LAHDEVIRTA J; SORSA T;
Indirizzi:
UNIV HELSINKI,DEPT PERIODONTOL,INST DENT,POB 41 MANNERHEIMINTIE 172 FIN-00014 HELSINKI FINLAND UNIV HELSINKI,DEPT PEDODONT & ORTHODONT,INST DENT FIN-00014 HELSINKI FINLAND UNIV HELSINKI,INST BIOMED,DEPT ANAT FIN-00014 HELSINKI FINLAND UNIV HELSINKI,CENT HOSP,DEPT MED,DIV RHEUMATOL HELSINKI FINLAND AURORA HOSP SF-00250 HELSINKI FINLAND UNIV OULU,INST DENT,DEPT ORAL SURG OULU FINLAND UNIV OULU,INST DENT,DEPT PATHOL OULU FINLAND
Titolo Testata:
Acta Odontologica Scandinavica
fascicolo: 3, volume: 56, anno: 1998,
pagine: 135 - 142
SICI:
0001-6357(1998)56:3<135:7A9GIS>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN NEUTROPHIL GELATINASE; TUMOR NECROSIS FACTOR; LOCALIZED JUVENILE PERIODONTITIS; GINGIVAL CREVICULAR FLUID; RECURRENT APHTHOUS ULCERS; MATRIX METALLOPROTEINASES; MONOCYTIC CELLS; HIV-1 INFECTION; MONONUCLEAR PHAGOCYTES; BACTEROIDES-GINGIVALIS;
Keywords:
MATRIX METALLOPROTEINASES; ORAL FLUIDS; PERIODONTITIS; TYPE IV COLLAGENASES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
L. Mellanen et al., "72-KDA AND 92-KDA GELATINASES IN SALIVA OF PATIENTS WITH HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION", Acta Odontologica Scandinavica, 56(3), 1998, pp. 135-142

Abstract

Human immunodeficiency virus (HIV infection has been associated with periodontal diseases in HIV-seropositive patients. In periodontal diseases, matrix metalloproteinases (MMPs) may play key roles in the extracellular matrix, basement membrane, serpin degradation, and modification of cytokine action. We characterized the 72 kDa type TV collagenase(gelatinase A, MMP-2) and 92 kDa type IV collagenase (gelatinase B, MMP-9) in the saliva of HIV-seropositive patients and seronegative healthy controls by activity measurements and quantitative immunoblotting. Immunoblot analysis with specific antibodies against MMP-2 and MMP-9 and their tissue inhibitors (TIMP-1, TIMP-2) disclosed that, independent of the phase of the patients' HIV infection, their sal;vary samplescontained higher amounts of MMP-2 and MMP-9 immunoreactivities in pro- and active forms and the TIMP-1 and TIMP-2 inhibitors than did the control samples. Healthy control saliva contained only slight immunoreactivities for gelatinases and TIMPs. However, as judged by the studiedclinical and microbiologic indicators, HIV-seropositive patients showed only a slight tendency to develop periodontitis. Overall, an increased amount of gelatinases in saliva may reflect increased host response and defense activities in HIV infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 13:17:26