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Titolo:
HYPERLEPTINAEMIA IN MICE INDUCED BY ADMINISTRATION OF THE TYROSINE-HYDROXYLASE INHIBITOR ALPHA-METHYL-P-TYROSINE
Autore:
RAYNER DV; SIMON E; DUNCAN JS; TRAYHURN P;
Indirizzi:
ROWETT RES INST,MOL PHYSIOL GRP ABERDEEN AB21 9SB SCOTLAND ROWETT RES INST,MOL PHYSIOL GRP ABERDEEN AB21 9SB SCOTLAND UNIV PAIS VASCO,DEPT NUTR & FOOD SCI VITORIA 01006 SPAIN
Titolo Testata:
FEBS letters
fascicolo: 3, volume: 429, anno: 1998,
pagine: 395 - 398
SICI:
0014-5793(1998)429:3<395:HIMIBA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
OB GENE-EXPRESSION; WHITE ADIPOSE-TISSUE; CIRCULATING LEPTIN LEVELS; OBESE GENE; FOOD-INTAKE; 3T3-L1 ADIPOCYTES; COLD-EXPOSURE; OB/OB MICE; PROTEIN; SYSTEM;
Keywords:
ALPHA-METHYL-P-TYROSINE; BETA-3-ADRENOCEPTOR; LEPTIN; OB GENE; SYMPATHETIC NERVOUS SYSTEM; WHITE ADIPOSE TISSUE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
D.V. Rayner et al., "HYPERLEPTINAEMIA IN MICE INDUCED BY ADMINISTRATION OF THE TYROSINE-HYDROXYLASE INHIBITOR ALPHA-METHYL-P-TYROSINE", FEBS letters, 429(3), 1998, pp. 395-398

Abstract

alpha-methyl-p-tyrosine (alpha MPT), an inhibitor of tyrosine hydroxylase, was administered to mice to block noradrenaline synthesis. Ten hours after injection of alpha MPT there was a 6-fold increase in plasma leptin. The level of ob mRNA in epididymal white adipose tissue mas also increased, but UCP1 mRNA in brown fat fell. In contrast to lean mice, ob mRNA in white fat of oblob mice was not increased by alpha MPT. alpha MPT raised plasma leptin in fasted as well as fed mice. Hyperleptinaemia was attenuated by treatment with a beta(3)-adrenoceptor agonist, Inhibition of noradrenaline synthesis leads to the rapid induction of hyperleptinaemia; it is suggested that sympathetic tone plays a pivotal role in regulating leptin production. (C) 1998 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 17:08:31