Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
TYPE-I TRANSFORMING-GROWTH-FACTOR-BETA RECEPTOR MAPS TO 9Q22 AND EXHIBITS A POLYMORPHISM AND A RARE VARIANT WITHIN A POLYALANINE TRACT
Autore:
PASCHE B; LUO Y; RAO PH; NIMER SD; DMITROVSKY E; CARON P; LUZZATTO L; OFFIT K; CORDONCARDO C; RENAULT B; SATAGOPAN JM; MURTY VVVS; MASSAGUE J;
Indirizzi:
MEM SLOAN KETTERING CANC CTR,CELL BIOL PROGRAM,1275 YORK AVE,BOX 116 NEW YORK NY 10021 MEM SLOAN KETTERING CANC CTR,CELL BIOL PROGRAM NEW YORK NY 10021 MEM SLOAN KETTERING CANC CTR,DEPT MED NEW YORK NY 10021 MEM SLOAN KETTERING CANC CTR,DEPT HUMAN GENET NEW YORK NY 10021 MEM SLOAN KETTERING CANC CTR,DEPT PATHOL NEW YORK NY 10021 MEM SLOAN KETTERING CANC CTR,DEPT BIOSTAT & EPIDEMIOL NEW YORK NY 10021 MEM SLOAN KETTERING CANC CTR,HOWARD HUGHES MED INST NEW YORK NY 10021 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT MOL GENET BRONX NY 10461 COLUMBIA UNIV,COLL PHYS & SURG,DEPT PATHOL NEW YORK NY 10021
Titolo Testata:
Cancer research
fascicolo: 13, volume: 58, anno: 1998,
pagine: 2727 - 2732
SICI:
0008-5472(1998)58:13<2727:TTRMT9>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-SUPPRESSOR GENE; HUMAN LUNG CANCERS; TGF-BETA; DPC4 GENE; MICROSATELLITE INSTABILITY; VIVO ALTERATIONS; CARCINOMA-CELLS; 18Q21; COMPLEMENTATION; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
B. Pasche et al., "TYPE-I TRANSFORMING-GROWTH-FACTOR-BETA RECEPTOR MAPS TO 9Q22 AND EXHIBITS A POLYMORPHISM AND A RARE VARIANT WITHIN A POLYALANINE TRACT", Cancer research, 58(13), 1998, pp. 2727-2732

Abstract

In a search for mutations of the type I transforming growth factor beta receptor (T beta R-I), we mapped the gene to 9q22 and found a common polymorphism [T beta R-I(6A)] and a rare variant [T beta R-I(10A)] of T beta R-I, causing an in-frame deletion of three alanines and an in-frame insertion of one alanine, respectively, in the receptor's extracellular domain. The biological relevance of the polymorphism T beta R-I(6A) was investigated. When T beta R-I(6A) was transiently transfected into T beta R-I-deficient cells, the growth-inhibitory effects of transforming growth factor beta were restored. T beta R-I(6A) and T beta R-I(10A) frequency were assessed in 108 tumor samples and 80 nontumor samples from patients with a diagnosis of cancer, as wed as in 118 normal blood donors of comparable ethnic composition. The frequency of T beta R-I(6A) heterozygotes was fairly similar in normal blood donors(8%), in nontumor DNA of patients with a diagnosis of cancer (10%), and in tumor samples (14%), However, the frequency of T beta R-I(6A) homozygotes among nontumor (4%) and tumor (8%) samples obtained from patients with a diagnosis of cancer was higher than that predicted hy theHardy-Weinberg law. The clinical and biological significance of T beta R-I(6A) homozygosity needs to be further investigated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 20:36:15