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Titolo:
THE DECLINE IN CD4-LYMPHOCYTES AS A FUNCTION OF THE DURATION OF HIV-INFECTION, AGE AT SEROCONVERSION, AND VIRAL LOAD( T)
Autore:
SORIANO V; CASTILLA J; GOMEZCANO M; HOLGUIN A; VILLALBA N; MAS A; GONZALEZLAHOZ J;
Indirizzi:
C RAFAEL CALVO 7,2 A MADRID 28010 SPAIN INST SALUD CARLOS III,INFECT DIS SERV MADRID SPAIN INST SALUD CARLOS III,NATL CTR EPIDEMIOL MADRID SPAIN
Titolo Testata:
The Journal of infection
fascicolo: 3, volume: 36, anno: 1998,
pagine: 307 - 311
SICI:
0163-4453(1998)36:3<307:TDICAA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
DYNAMICS IN-VIVO; NATURAL-HISTORY; REVERSE-TRANSCRIPTASE; RNA LEVELS; PLASMA; AIDS; QUANTIFICATION; THERAPY; DISEASE; VIRUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
V. Soriano et al., "THE DECLINE IN CD4-LYMPHOCYTES AS A FUNCTION OF THE DURATION OF HIV-INFECTION, AGE AT SEROCONVERSION, AND VIRAL LOAD( T)", The Journal of infection, 36(3), 1998, pp. 307-311

Abstract

Background: The rate of CD4+ T-lymphocyte decline seen in HIV-infected patients is very variable. Although older patients, a longer duration of HIV infection, and a high level of plasma viraemia, have been associated with a faster fall in CD4+ T-cells, the relationship between these variables is still not well known. Patients and methods: In a cross-sectional study that included a total of 107 patients of known age and date at HIV seroconversion, the current CD4+ T-cell count and plasma viraemia were examined. Patients were not taking antiretroviral drugs, nor had received immunizations nor were suffering any intercurrentinfections at the time of the study. Results: The mean duration of HIV infection was 8.6 +/- 2.9 years. The mean CD4+ T-lymphocyte count was 367 +/- 264 x 10(6)/l. Mean plasma viraemia was 4.3 +/- 0.9 logs. Ina linear regression model, the current CD4+ T-cell count was explained in 21.7% by the duration of HIV infection, while the level of plasmaviraemia justified separately up to 37.0%. When both parameters were combined, they explained 58.8% of the CD4+ lymphocyte values. In this model, a variation of one logarithm in the plasma viraemia had six times greater effect on the number of CD4+ lymphocytes than each year of HIV infection. When the age at seroconversion was added to the model, the CD4+ cell count allowed the explanation of up to 62.2% of cases. Conclusions: The age at seroconversion, the duration of HIV infection, and the level of plasma viraemia independently and substantially influence the current CD4+ lymphocyte count in HIV-infected subjects. However, other variables should exist (e.g. virus syncytium-inducing phenotype, host immunogenetic repertoire, etc.), contributing to explaining the different rate of CD4+ T-cell decline seen in HIV-infected subjects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 15:19:19