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Titolo:
ACTIVATION OF METABOTROPIC GLUTAMATE RECEPTORS DELAYS APOPTOSIS OF CHICK EMBRYONIC MOTOR-NEURONS IN-VITRO
Autore:
ANNESER JMH; HORSTMANN S; WEYDT P; BORASIO GD;
Indirizzi:
UNIV MUNICH,KLINIKUM GROSSHADERN,NEUROL KLIN D-81366 MUNICH GERMANY UNIV MUNICH,KLINIKUM GROSSHADERN,NEUROL KLIN D-81366 MUNICH GERMANY
Titolo Testata:
NeuroReport
fascicolo: 9, volume: 9, anno: 1998,
pagine: 2039 - 2043
SICI:
0959-4965(1998)9:9<2039:AOMGRD>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYOTROPHIC-LATERAL-SCLEROSIS; CEREBELLAR GRANULE CELLS; CULTURE; SURVIVAL; AGONIST; ANTAGONIST; MUSCLE; POTENT; ACID;
Keywords:
AMYOTROPHIC LATERAL SCLEROSIS; GLUTAMATE RECEPTORS; IN SITU HYBRIDIZATION; MOTOR NEURONS; NEURONAL APOPTOSIS; SIGNAL TRANSDUCTION; TISSUE CULTURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
J.M.H. Anneser et al., "ACTIVATION OF METABOTROPIC GLUTAMATE RECEPTORS DELAYS APOPTOSIS OF CHICK EMBRYONIC MOTOR-NEURONS IN-VITRO", NeuroReport, 9(9), 1998, pp. 2039-2043

Abstract

GLUTAMATERGIC excitotoxicity has been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). However, activation of metabotropic glutamate receptors (mGluRs) is neuroprotective in several paradigms. We therefore tested the effect of selective mGluR agonists on cultured chick embryonic motor neurons. Activation of group I mGluRs with (s)-3,5-dihydroxyphenylglycine (DHPG) and group III mGluRs with L-2-amino-4-phosphono-butanoate (L-AP4) promoted a modest but significant,dose-dependent delay of apoptosis, which could be blocked by specificmGluR antagonists. Group II or selective mGluR5 stimulations were ineffective. Correspondingly, in situ hybridization experiments showed only expression of mGluR1 (group I) and mGluR4 and 7 (group III) in human motor neurons. Dissection of the pathways involved in this survival effect may help to elucidate the pathogenesis of ALS. (C) 1998 Rapid Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 00:14:01