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Titolo:
A SMALL, NONPEPTIDYL MIMIC OF GRANULOCYTE-COLONY-STIMULATING FACTOR
Autore:
TIAN SS; LAMB P; KING AG; MILLER SG; KESSLER L; LUENGO JI; AVERILL L; JOHNSON RK; GLEASON JG; PELUS LM; DILLON SB; ROSEN J;
Indirizzi:
LIGAND PHARMACEUT INC,DEPT TRANSCRIPT RES SAN DIEGO CA 92121 LIGAND PHARMACEUT INC,DEPT TRANSCRIPT RES SAN DIEGO CA 92121 SMITHKLINE BEECHAM PHARMACEUT,DEPT MOL VIROL & HOST DEF US COLLEGEVILLE PA 19426 LIGAND PHARMACEUT INC,DEPT NEW LEADS DISCOVERY SAN DIEGO CA 92121 SMITHKLINE BEECHAM PHARMACEUT,DEPT MED CHEM US COLLEGEVILLE PA 19426 SMITHKLINE BEECHAM PHARMACEUT,DEPT ONCOL KING OF PRUSSIA PA 19406
Titolo Testata:
Science
fascicolo: 5374, volume: 281, anno: 1998,
pagine: 257 - 259
SICI:
0036-8075(1998)281:5374<257:ASNMOG>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-RECEPTOR; TYROSINE PHOSPHORYLATION; CELL-LINE; STAT3; ERYTHROPOIETIN; INTERLEUKIN-6; DIMERIZATION; BINDING; CSF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
S.S. Tian et al., "A SMALL, NONPEPTIDYL MIMIC OF GRANULOCYTE-COLONY-STIMULATING FACTOR", Science, 281(5374), 1998, pp. 257-259

Abstract

A nonpeptidyl small molecule SB 247464, capable of activating granulocyte-colony-stimulating factor (G-CSF) signal transduction pathways, was identified in a high-throughput assay in cultured cells. Like G-CSF, SE 247464 induced tyrosine phosphorylation of multiple signaling proteins and stimulated primary murine bone marrow cells to form granulocytic colonies in vitro. It also elevated peripheral blood neutrophil counts in mice. The extracellular domain of the murine G-CSF receptor was required for the activity of SE 247464, suggesting that the compound acts by oligomerizing receptor chains. The results indicate that a small molecule can activate a receptor that normally binds a relativelyLarge protein Ligand.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:36:27