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Titolo:
IMMUNIZATION OF COMMON MARMOSETS WITH EPSTEIN-BARR-VIRUS (EBV) ENVELOPE GLYCOPROTEIN GP340 - EFFECT ON VIRAL SHEDDING FOLLOWING EBV CHALLENGE
Autore:
COX C; NAYLOR BA; MACKETT M; ARRAND JR; GRIFFIN BE; WEDDERBURN N;
Indirizzi:
HAMMERSMITH HOSP,ICSM,DEPT INFECT DIS,DIV INVEST SCI LONDON W12 0NN ENGLAND HAMMERSMITH HOSP,ICSM,DEPT INFECT DIS,DIV INVEST SCI LONDON W12 0NN ENGLAND ROYAL COLL SURGEONS ENGLAND,DEPT PATHOL LONDON WC2A 3PN ENGLAND CHRISTIE HOSP NHS TRUST,DEPT BIOL MOL,PATERSON INST CANC RES MANCHESTER M20 4BX LANCS ENGLAND
Titolo Testata:
Journal of medical virology
fascicolo: 4, volume: 55, anno: 1998,
pagine: 255 - 261
SICI:
0146-6615(1998)55:4<255:IOCMWE>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE INFECTIOUS-MONONUCLEOSIS; INDUCED MALIGNANT-LYMPHOMAS; COTTONTOP TAMARINS; MEMBRANE ANTIGEN; SEROPOSITIVE INDIVIDUALS; CALLITHRIX-JACCHUS; EXPRESSION VECTOR; HOST BALANCE; VACCINE; ANTIBODIES;
Keywords:
EBV VACCINE; PCR; BUCCAL FLUIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
C. Cox et al., "IMMUNIZATION OF COMMON MARMOSETS WITH EPSTEIN-BARR-VIRUS (EBV) ENVELOPE GLYCOPROTEIN GP340 - EFFECT ON VIRAL SHEDDING FOLLOWING EBV CHALLENGE", Journal of medical virology, 55(4), 1998, pp. 255-261

Abstract

Epstein-Barr virus (EBV), the cause of infectious mononucleosis, is involved in the pathogenesis of several human cancers, the highest frequency of association being found in undifferentiated nasopharyngeal carcinoma and endemic Burkitt's lymphoma. The development of animal models in which potential vaccines can be tested is important. EBV infection of the common marmoset, using the M81 strain originally derived from a patient with nasopharyngeal carcinoma, induces a carrier state in this animal. Persistent infection is characterized by the production of antibodies to viral antigens, and the secretion of EBV DNA into buccal fluids. Following immunization with envelope glycoprotein gp340 derived from a bovine papilloma virus expression vector, prior to EBV infection, viral DNA was detected significantly less frequently in the buccal fluids of immunized, than of nonimmunized, infected animals, indicating that although the carrier state had not been abolished, it had been altered. A reduction in virus load was also observed when offspring of seronegative, and on occasion seropositive, parents were immunized neonatally, before EBV challenge. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 13:12:51