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Titolo:
CHEMOKINE RECEPTOR POLYMORPHISM AND AUTOLOGOUS NEUTRALIZING ANTIBODY-RESPONSE IN LONG-TERM HIV-1 INFECTION
Autore:
SCHONNING K; JOOST M; GRAM GJ; MACHUCA R; NIELSEN C; NIELSEN JO; HANSEN JES;
Indirizzi:
UNIV COPENHAGEN,HVIDOVRE HOSP,DEPT INFECT DIS 144 DK-2650 HVIDOVRE DENMARK UNIV COPENHAGEN,HVIDOVRE HOSP,DEPT INFECT DIS 144 DK-2650 HVIDOVRE DENMARK STATENS SERUM INST,DEPT VIROL,RETROVIRUS LAB DK-2300 COPENHAGEN DENMARK
Titolo Testata:
Journal of acquired immune deficiency syndromes and human retrovirology
fascicolo: 3, volume: 18, anno: 1998,
pagine: 195 - 202
SICI:
1077-9450(1998)18:3<195:CRPAAN>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; TYPE-1 VARIANTS; ENTRY; PATHOGENESIS; PROGRESSION; ISOLATE; TROPISM; PLASMA; CELLS; SERA;
Keywords:
CHEMOKINE RECEPTOR POLYMORPHISM; AUTOLOGOUS NEUTRALIZING ANTIBODY RESPONSE; LONG-TERM HIV-1 INFECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
K. Schonning et al., "CHEMOKINE RECEPTOR POLYMORPHISM AND AUTOLOGOUS NEUTRALIZING ANTIBODY-RESPONSE IN LONG-TERM HIV-1 INFECTION", Journal of acquired immune deficiency syndromes and human retrovirology, 18(3), 1998, pp. 195-202

Abstract

We have previously reported that slowly progressing HIV infection (SPI) was associated with the presence of contemporaneous autologous neutralizing anti-bodies. In contrast, a group of individuals with more rapidly progressing infection (RPI) generally lacked these antibodies. To understand the importance of autologous neutralizing antibodies in SPI more fully, we have now conducted a prospective study taking consecutive blood samples from the individuals with SPI (8 patients) and RPI(10 patients). Blood sampling in the group with SPI was done 110 and 123 months after the estimated seroconversion and at similar time points in the group with RPI. Virus isolation was attempted at both time points in both groups of individuals; crossed neutralization assays were set up with autologous virus. These confirmed our previous finding of significant autologous neutralizing titers in the group with SPI (geometric mean titer [GMT] 8.7 versus 1.6 in SPI and RPI, respectively; p = 0.0048). However, not all individuals with SPI possessed autologous neutralizing antibody titers did not increase from early to late serum samples. Finally, late virus isolates from individuals with SPI generally remained sensitive to neutralization by early serum samples. Virus phenotype (SI/NSI) and CCR5 genotype was determined for all individuals.Neither showed significant correlation with SPI. However, all SPI individuals who were heterozygous for the CCR5 deletion were infected with virus of NSI phenotype. In contrast, all RPI individuals who were heterozygous for the CCR5 deletion were infected with virus SI phenotype (p = .028). Thus, a beneficial effect of having a partly nonfunctional CCR5 coreceptor may depend on the viral SI/NSI phenotype.

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Documento generato il 28/11/20 alle ore 09:47:39