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Titolo:
LYMPHOCYTIC HYPOPHYSITIS - LIGHT AND ELECTRON-MICROSCOPIC FINDINGS AND CORRELATION TO CLINICAL-APPEARANCE
Autore:
FEHN M; SOMMER C; LUDECKE DK; PLOCKINGER U; SAEGER W;
Indirizzi:
ALFREDSTR 9 D-22087 HAMBURG GERMANY MARIEN HOSP,INST PATHOL D-22087 HAMBURG GERMANY UNIV HAMBURG,HOSP EPPENDORF,CLIN NEUROSURG D-20246 HAMBURG GERMANY FREE UNIV BERLIN,CLIN BENJAMIN FRANKLIN,DEPT ENDOCRINOL D-12203 BERLIN GERMANY UNIV HEIDELBERG,INST NEUROPATHOL D-69120 HEIDELBERG GERMANY
Titolo Testata:
Endocrine pathology
fascicolo: 1, volume: 9, anno: 1998,
pagine: 71 - 78
SICI:
1046-3976(1998)9:1<71:LH-LAE>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
GRANULOMATOUS HYPOPHYSITIS; PITUITARY; ADENOHYPOPHYSITIS; HYPOPITUITARISM;
Keywords:
LYMPHOCYTIC HYPOPHYSITIS; PITUITARY TUMOR; MORPHOLOGY; IMMUNOCYTOCHEMISTRY; ELECTRON MICROSCOPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
M. Fehn et al., "LYMPHOCYTIC HYPOPHYSITIS - LIGHT AND ELECTRON-MICROSCOPIC FINDINGS AND CORRELATION TO CLINICAL-APPEARANCE", Endocrine pathology, 9(1), 1998, pp. 71-78

Abstract

Light and electron microscopic findings of six cases of lymphocytic hypophysitis of a collective of 2500 surgical specimens are presented. Five cases were obtained by surgery, one case was obtained from autopsy. Light microscopy revealed an infiltration of mature lymphocytes andplasma cells in the interstitium, partly in the acini, as well as in the posterior lobe and the capsule. The structure of the remaining anterior lobe was normal. The final stage of lymphocytic hypophysitis is fibrosis, which was seen in all cases to varying degrees. The infiltrate consisted mainly of T-lymphocytes, being positive for CK 45 RO and CD 43. Immunocytochemical staining revealed different proportions of residual adenohypophyseal cells, Mainly prolactin reactive cells were observed as were growth hormone reactive cells. By electron microscopy same ruptured acini and damaged adenohypophyseal cells could be seen. Few pituitary cells contained enlarged lysosomal bodies or oncocytic changes. Inflammation causing enlargement of the pituitary leads to patients often being operated under the preoperative diagnosis of a tumorof the sellar region. It is important to identify this special type of hypophysitis, as a different course of treatment is required.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:49:58