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Titolo:
CENTRAL-NERVOUS-SYSTEM ORIGINS OF THE SYMPATHETIC NERVOUS-SYSTEM OUTFLOW TO WHITE ADIPOSE-TISSUE
Autore:
BAMSHAD M; AOKI VT; ADKISON MG; WARREN WS; BARTNESS TJ;
Indirizzi:
GEORGIA STATE UNIV,DEPT PSYCHOL,UNIV PLAZA ATLANTA GA 30303 GEORGIA STATE UNIV,DEPT PSYCHOL ATLANTA GA 30303 GEORGIA STATE UNIV,DEPT BIOL ATLANTA GA 30303 GEORGIA STATE UNIV,DEPT NEUROPSYCHOL & BEHAV NEUROSCI ATLANTA GA 30303 GEORGIA STATE UNIV,NEUROBIOL PROGRAMS ATLANTA GA 30303
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 1, volume: 44, anno: 1998,
pagine: 291 - 299
SICI:
0363-6119(1998)44:1<291:COOTSN>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSOMEDIAL HYPOTHALAMIC NUCLEUS; PSEUDORABIES VIRUS; SPINAL-CORD; PARAVENTRICULAR NUCLEUS; PREGANGLIONIC NEURONS; REGIONAL DIFFERENCES; FOOD-INTAKE; RAT; OBESITY; MOBILIZATION;
Keywords:
PSEUDORABIES VIRUS; HAMSTERS; RATS; LIPOLYSIS; OBESITY; PARAVENTRICULAR NUCLEUS; SUPRACHIASMATIC NUCLEUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
M. Bamshad et al., "CENTRAL-NERVOUS-SYSTEM ORIGINS OF THE SYMPATHETIC NERVOUS-SYSTEM OUTFLOW TO WHITE ADIPOSE-TISSUE", American journal of physiology. Regulatory, integrative and comparative physiology, 44(1), 1998, pp. 291-299

Abstract

White adipose tissue (WAT) is innervated by postganglionic sympathetic nervous system (SNS) neurons, suggesting that lipid mobilization could be regulated by the SNS [T. G. Youngstrom and T. J. Bartness. Am. J. Physiol. 268 (Regulatory Integrative Comp. Physiol. 37): R744-R751, 1995]. A viral transsynaptic retrograde tract tracer, the pseudorabiesvirus (PRV), was used to identify the origins of the SNS outflow fromthe brain to WAT neuroanatomically. PRV was injected into epididymal or inguinal WAT (EWAT and IWAT, respectively) of Siberian hamsters andIWAT of rats. PRV-infected neurons were visualized by immunocytochemistry and found in the spinal cord, brain stem (medulla, nucleus of thesolitary tract, caudal raphe nucleus, C1 and A5 regions), midbrain (central gray), and several areas within the forebrain. The general pattern of infection of WAT in both species was more similar than different and resembled that seen after PRV injections into the adrenal medulla in rats (A. M. Strack, W. B. Sawyer, J. H. Hughes, K. B. Platt, and A. D. Loewy. Brain Res. 491: 156-162, 1989). EWAT versus IWAT injectedhamsters had relatively less labeling in the suprachiasmatic, dorsomedial, and arcuate nuclei. Overall, it appeared that the SNS innervation of WAT originates from the general SNS outflow of the central nervous system and therefore may play a significant role in lipid mobilization.

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Documento generato il 25/09/20 alle ore 00:25:03