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Titolo:
CLINICAL-APPLICATION OF K-RAS ONCOGENE MUTATIONS IN PANCREATIC-CARCINOMA - DETECTION OF MICROMETASTASES
Autore:
NOMOTO S; NAKAO A; ANDO N; TAKEDA S; KASAI Y; INOUE S; KANEKO T; TAKAGI H;
Indirizzi:
NAGOYA UNIV,SCH MED,DEPT SURG 2,SHOWA KU,65 TSURUMAI CHO NAGOYA AICHI466 JAPAN
Titolo Testata:
Seminars in surgical oncology
fascicolo: 1, volume: 15, anno: 1998,
pagine: 40 - 46
SICI:
8756-0437(1998)15:1<40:COKOMI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPH-NODE METASTASES; HEAD CARCINOMA; PORTAL-VEIN; ADENOCARCINOMA; GENE; DIAGNOSIS; CATHETER; INVASION; CANCER; BLOOD;
Keywords:
PANCREATIC NEOPLASMS GENETICS PATHOLOGY MORTALITY; RAS GENES; CODON; ADENOCARCINOMA/GENETICS/PATHOLOGY/MORTALITY; POLYMERASE CHAIN REACTION; SURVIVAL RATE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; MUTATION; NEOPLASM INVASIVENESS; CA-19-9 ANTIGEN; CARCINOEMBRYONIC ANTIGEN; LIVER NEOPLASMS; NEOPLASM METASTASIS; SENSITIVITY AND SPECIFICITY; PORTAL VEIN SURGERY; LYMPH NODE EXCISION; LYMPHATIC METASTASIS; STAINING;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
S. Nomoto et al., "CLINICAL-APPLICATION OF K-RAS ONCOGENE MUTATIONS IN PANCREATIC-CARCINOMA - DETECTION OF MICROMETASTASES", Seminars in surgical oncology, 15(1), 1998, pp. 40-46

Abstract

Pancreatic adenocarcinomas are known to have a high incidence of K-ras gene mutation. We summarize our efforts to detect micrometastases through a search for mutated K-ras oncogene in liver tissues, peritonealwashings, para-aortic lymph nodes, and perioperative peripheral blood. Two-stage polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis were used to detect K-ras oncogene mutations at codon 12. Our results suggest that PCR/RFLP analysis is potentially highly sensitive for the detection of micrometastases in various tissues and might be of value in the diagnosis, treatment and follow-up of metastases in other organs with pancreatic adenocarcinoma. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 03:43:23