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Titolo:
ANXIETY PRONENESS LINKED TO EPISTATIC LOCI IN GENOME SCAN OF HUMAN PERSONALITY-TRAITS
Autore:
CLONINGER CR; VANEERDEWEGH P; GOATE A; EDENBERG HJ; BLANGERO J; HESSELBROCK V; REICH T; NURNBERGER J; SCHUCKIT M; PORJESZ B; CROWE R; RICE JP; FOROUD T; PRZYBECK TR; ALMASY L; BUCHOLZ K; WU W; SHEARS S; CARR K; CROSE C; WILLIG C; ZHAO J; TISCHFIELD JA; LI TK; CONNEALLY PM; BEGLEITER H;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT,4940 CHILDRENS PL ST LOUIS MO 63110 GENOME THERAPEUT WALTHAM MA 00000 INDIANA UNIV,SCH MED,DEPT PSYCHIAT INDIANAPOLIS IN 46202 SW FDN BIOMED RES SAN ANTONIO TX 78284 UNIV CONNECTICUT,SCH MED,DEPT PSYCHIAT FARMINGTON CT 00000 UNIV CALIF SAN DIEGO,SCH MED SAN DIEGO CA 92103 SUNY HLTH SCI CTR,DEPT PSYCHIAT BROOKLYN NY 11203 UNIV IOWA,SCH MED,DEPT PSYCHIAT IOWA CITY IA 52242
Titolo Testata:
American journal of medical genetics
fascicolo: 4, volume: 81, anno: 1998,
pagine: 313 - 317
SICI:
0148-7299(1998)81:4<313:APLTEL>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECOMBINANT INBRED MICE; NOVELTY SEEKING; GENETICS; POLYMORPHISM; ASSOCIATION; TEMPERAMENT; ALCOHOLISM; LINKAGE; REGION; MODEL;
Keywords:
LINKAGE; PERSONALITY; EPISTASIS; ALCOHOLISM; GENOME SCAN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
C.R. Cloninger et al., "ANXIETY PRONENESS LINKED TO EPISTATIC LOCI IN GENOME SCAN OF HUMAN PERSONALITY-TRAITS", American journal of medical genetics, 81(4), 1998, pp. 313-317

Abstract

A genome-wide scan between normal human personality traits and a set of genetic markers at an average interval of 13 centimorgans was carried out in 758 pairs of siblings in 177 nuclear families of alcoholics. Personality traits were measured by the Tridimensional Personality Questionnaire. We detected significant linkage between the trait Harm Avoidance, a measure of anxiety proneness, and a locus on chromosome 8p21-23 that explained 38% of the trait variance. There was significant evidence of epistasis between the locus on 8p and others on chromosomes18p, 20p, and 21q. These oligogenic interactions explained most of the variance in Harm Avoidance. There was suggestive evidence of epistasis in other personality traits. These results confirm the important influence of epistasis on human personality suggested by twin and adoption studies. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 81:313-317, 1998. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 10:32:38