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Titolo:
FURTHER INVESTIGATION OF A CHROMOSOME-15 LOCUS IN SCHIZOPHRENIA - ANALYSIS OF AFFECTED SIBPAIRS FROM THE NIMH-GENETICS-INITIATIVE
Autore:
LEONARD S; GAULT J; MOORE T; HOPKINS J; ROBINSON M; OLINCY A; ADLER LE; CLONINGER CR; KAUFMANN CA; TSUANG MT; FARAONE SV; MALASPINA D; SVRAKIC DM; FREEDMAN R;
Indirizzi:
UNIV COLORADO,HLTH SCI CTR,DEPT PSYCHIAT C268 71,4200 E 9TH AVE DENVER CO 80262 UNIV COLORADO,HLTH SCI CTR,DEPT PSYCHIAT C268 71 DENVER CO 80262 UNIV COLORADO,HLTH SCI CTR,DEPT PHARMACOL DENVER CO 80262 VET ADM MED CTR DENVER CO 80220 WASHINGTON UNIV,NIMH GENET INITIAT ST LOUIS MO 00000 COLUMBIA UNIV,NIMH GENET INITIAT NEW YORK NY 00000 HARVARD UNIV,NIMH GENET INITIAT CAMBRIDGE MA 02138
Titolo Testata:
American journal of medical genetics
fascicolo: 4, volume: 81, anno: 1998,
pagine: 308 - 312
SICI:
0148-7299(1998)81:4<308:FIOACL>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUDITORY EVOKED-RESPONSES; NICOTINIC RECEPTORS; LINKAGE ANALYSIS; NORMALIZATION; HETEROGENEITY; PHYSIOLOGY; STRATEGIES; RELATIVES; DEFICITS;
Keywords:
HUMAN CHROMOSOME PAIR 15; GENETIC LINKAGE; NICOTINIC RECEPTOR; POLYMORPHISM; AUDITORY EVOKED POTENTIAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
S. Leonard et al., "FURTHER INVESTIGATION OF A CHROMOSOME-15 LOCUS IN SCHIZOPHRENIA - ANALYSIS OF AFFECTED SIBPAIRS FROM THE NIMH-GENETICS-INITIATIVE", American journal of medical genetics, 81(4), 1998, pp. 308-312

Abstract

Linkage of a neurophysiological deficit associated with schizophrenia, i.e., the failure to inhibit the auditory P50 response, was previously reported at chromosome 15q14, The marker with the highest pairwise lod score, D15S1360, was isolated from a yeast artificial chromosome containing a candidate gene, the alpha 7-nicotinic acetylcholine receptor gene, In the present study, this linkage was further investigated in a subset of the NIMH Genetics Initiative schizophrenia families, These families have not been studied neurophysiologically, as were the families in the original report, Therefore, the DSMIII-R diagnosis of schizophrenia was used as the affected phenotype, Twenty families fulfilled the criteria of at least one sibpair concordant for schizophrenia,along with their two parents or another affected relative outside thenuclear family, available for genotyping. Sibpair analysis showed a significant proportion of D15S1360 alleles shared identical-by-descent (0.58; P < 0.0024). The results further support the involvement of this chromosomal locus in the genetic transmission of schizophrenia, Am, J, Med, Genet, (Neuropsychiatr, Genet,) 81:308-312, 1998, (C) 1998 Wiley-Liss, Inc.

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Documento generato il 23/01/20 alle ore 03:21:03