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Titolo:
5,6-EPOXYEICOSATRIENOIC ACID REDUCES INCREASES IN PULMONARY VASCULAR-RESISTANCE IN THE DOG
Autore:
STEPHENSON AH; SPRAGUE RS; LONIGRO AJ;
Indirizzi:
ST LOUIS UNIV,SCH MED,DEPT PHARMACOL & PHYSIOL SCI,1402 S GRAND BLVD ST LOUIS MO 63104 ST LOUIS UNIV,SCH MED,DEPT INTERNAL MED ST LOUIS MO 63104
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 1, volume: 44, anno: 1998,
pagine: 100 - 109
SICI:
0363-6135(1998)44:1<100:5ARIIP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE LUNG INJURY; RAM SEMINAL-VESICLES; ARACHIDONIC-ACID; EPOXYEICOSATRIENOIC ACIDS; CORONARY-ARTERIES; CYCLOOXYGENASE; METABOLITES; CYTOCHROME-P450; THROMBOXANE; RESPONSES;
Keywords:
THROMBOXANE; PROSTACYCLIN; CYCLOOXYGENASE; PULMONARY VASCULATURE; SEGMENTAL RESISTANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
A.H. Stephenson et al., "5,6-EPOXYEICOSATRIENOIC ACID REDUCES INCREASES IN PULMONARY VASCULAR-RESISTANCE IN THE DOG", American journal of physiology. Heart and circulatory physiology, 44(1), 1998, pp. 100-109

Abstract

We recently reported that canine pulmonary microsomes metabolize arachidonic acid to all four regioisomeric epoxyeicosatrienoic acids (EET). 5,6-EET dilates blood vessels in several nonpulmonary vascular beds,often in a cyclooxygenase-dependent manner. The present study was designed to determine whether 5,6-EET can decrease pulmonary vascular resistance (PVR) in the intact pulmonary circulation. In isolated canine lungs perfused with physiological salt solution, a constant infusion of U-46619 (3.28 +/- 0.99 nmol/min) increased PVR 62.1 +/- 4.5%. Administration of 5,6-EET (10(-5) M) into the perfusate reduced the U-46619-mediated increase in PVR by 23.6 +/- 6.1%. These effects of U-46619 and 5,6-EET were limited to changes in resistance solely in the pulmonary venous segment. In contrast, venous as well as arterial segmental resistances were increased in 5-hydroxytryptamine (5-HT)-treated lungs. However, in the latter instance, 5,6-EET reduced arterial but not venous segmental resistance. 5,6-EET increased pulmonary PGI(2) synthesis from 70.5 +/- 18.4 to 675.9 +/- 125.4 ng/min. In the presence of indomethacin (10(-4) M), 5,6-EET did not increase PGI2 synthesis nor did itdecrease U-46619- or 5-MT-mediated increases in PVR. In canine intrapulmonary vessels, 5,6-EET decreased active tension in veins contractedwith U-46619. 5,6-EET decreased active tension in arteries but not veins contracted with 5-HT, consistent with results in the perfused lungs. These results demonstrate that 5,6-EET is a vasodilator in the intact pulmonary circulation. Its dilator activity depends on the constrictor agent present, the segmental resistance, and cyclooxygenase activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:34:11