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Titolo:
AN ISOBOLOGRAPHIC ANALYSIS OF DRUG-INTERACTION BETWEEN INTRATHECAL CLONIDINE AND BACLOFEN IN THE FORMALIN TEST IN RATS
Autore:
PRZESMYCKI K; DZIECIUCH JA; CZUCZWAR SJ; KLEINROK Z;
Indirizzi:
MED UNIV SCH,DEPT ANAESTHESIOL & INTENS CARE,JACZEWSKIEGO 8 PL-20090 LUBLIN POLAND MED UNIV SCH,DEPT PHARMACOL & TOXICOL PL-20090 LUBLIN POLAND INST RURAL MED,DEPT CLIN TOXICOL PL-20090 LUBLIN POLAND
Titolo Testata:
Neuropharmacology
fascicolo: 2, volume: 37, anno: 1998,
pagine: 207 - 214
SICI:
0028-3908(1998)37:2<207:AIAODB>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPINAL-CORD; SUBSTANCE-P; DORSAL HORN; ANTINOCICEPTIVE ACTIVITY; RECEPTOR; MORPHINE; AGONISTS; NEURONS; PAIN; MECHANISMS;
Keywords:
CLONIDINE; BACLOFEN; NOCICEPTION; FORMALIN TEST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
K. Przesmycki et al., "AN ISOBOLOGRAPHIC ANALYSIS OF DRUG-INTERACTION BETWEEN INTRATHECAL CLONIDINE AND BACLOFEN IN THE FORMALIN TEST IN RATS", Neuropharmacology, 37(2), 1998, pp. 207-214

Abstract

The inhibition of both phases of the formalin response by intrathecal(IT) clonidine and baclofen, given alone or in combination at a fixeddose ratio, was studied. Both drugs, at doses not affecting motor performance, produced a dose-dependent inhibition of phase 2 of the formalin test. The potency of baclofen and clonidine, defined by their ID50's for phase 2 of the formalin test, was 0.56 and 3.4 nmol, respectively. The combination ID50 of baclofen and clonidine, with the equieffective dose ratio of 1:6, was found to be statistically lower than the theoretical additive ID50. These data suggest that co-administration ofalpha(2)-adrenoceptor or GABA(B) receptor agonists may prove therapeutically useful in treating chronic pain. (C) 1998 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 22:56:16