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Titolo:
BASAL FOREBRAIN CHOLINERGIC LESIONS ENHANCE CONDITIONED APPROACH RESPONSES TO STIMULI PREDICTIVE OF FOOD
Autore:
OLMSTEAD MC; ROBBINS TW; EVERITT BJ;
Indirizzi:
QUEENS UNIV,DEPT BIOL KINGSTON ON K7L 3N6 CANADA UNIV CAMBRIDGE,DEPT EXPT PSYCHOL CAMBRIDGE CB2 3EB ENGLAND
Titolo Testata:
Behavioral neuroscience
fascicolo: 3, volume: 112, anno: 1998,
pagine: 611 - 629
SICI:
0735-7044(1998)112:3<611:BFCLEC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-ACCUMBENS-SEPTI; INDUCED EXCITOTOXIC LESIONS; INDUCED LOCOMOTOR-ACTIVITY; MEDIAL PREFRONTAL CORTEX; REWARD-RELATED STIMULI; VENTRAL PALLIDUM; D-AMPHETAMINE; ACETYLCHOLINE-RELEASE; DOPAMINE-RECEPTORS; 6-HYDROXYDOPAMINE LESIONS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
120
Recensione:
Indirizzi per estratti:
Citazione:
M.C. Olmstead et al., "BASAL FOREBRAIN CHOLINERGIC LESIONS ENHANCE CONDITIONED APPROACH RESPONSES TO STIMULI PREDICTIVE OF FOOD", Behavioral neuroscience, 112(3), 1998, pp. 611-629

Abstract

This study examined the effects of lesions to different neuronal populations within the basal forebrain on reward-related learning. Rats received bilateral alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) or quinolinate lesions that preferentially destroy the cholinergic nucleus basalis magnocellularis (NBM) or noncholinergic ventral pallidal neurons, respectively. Both lesions enhanced conditioned approach responses to stimuli predictive of food but did not increase the locomotor stimulating effect of d-amphetamine. Although both lesions disrupted the discriminative control over behavior by a conditioned stimulus, they did not impair the subsequent acquisition of instrumental responding with conditioned reinforcement (CR). Indeed, both lesions were associated with an increased responding with CR following intra-accumbens infusions of d-amphetamine (0, 1, 3, 10, and 20 mu g). Quinolinate lesions also increased responses on an inactive control lever. Neither lesion altered consummatory responses to food or sucrose. Results suggest that NBM lesions may disrupt the balance between corticaland subcortical dopamine levels, and/or produce a deficit in attentional mechanisms that is manifested as increased responding to specific stimuli.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:14:04