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Titolo:
LOCAL AND SYSTEMIC DELIVERY OF LOW-MOLECULAR-WEIGHT HEPARIN FOLLOWINGPTCA - ACUTE RESULTS AND 6-MONTH FOLLOW-UP OF THE INITIAL CLINICAL-EXPERIENCE WITH THE POROUS BALLOON (PILOT-STUDY)
Autore:
OBERHOFF M; BAUMBACH A; HERMANN T; DIEHL C; MAIER R; ATHANASIADIS A; HERDEG C; BOHNET A; HAASE KK; VOELKER W; BAILDON R; VELDHOF S; KARSCH KR;
Indirizzi:
UNIV TUBINGEN,MED KLIN 3,OTFRIED MULLER STR 10 D-72076 TUBINGEN GERMANY UNIV TUBINGEN,DEPT MED,DIV CARDIOL TUBINGEN GERMANY KNOLL CO LUDWIGSHAFEN GERMANY GUIDANT CO SANTA CLARA CA 00000
Titolo Testata:
Catheterization and cardiovascular diagnosis
fascicolo: 3, volume: 44, anno: 1998,
pagine: 267 - 274
SICI:
0098-6569(1998)44:3<267:LASDOL>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; RESTENOSIS FOLLOWING ANGIOPLASTY; CORONARY ANGIOPLASTY; CELLULAR PROLIFERATION; INTIMAL HYPERPLASIA; HOLY-GRAIL; INHIBITION; ARTERY; PREVENTION; MIGRATION;
Keywords:
LOCAL DRUG DELIVERY; RESTENOSIS; PTCA; CLINICAL STUDY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
M. Oberhoff et al., "LOCAL AND SYSTEMIC DELIVERY OF LOW-MOLECULAR-WEIGHT HEPARIN FOLLOWINGPTCA - ACUTE RESULTS AND 6-MONTH FOLLOW-UP OF THE INITIAL CLINICAL-EXPERIENCE WITH THE POROUS BALLOON (PILOT-STUDY)", Catheterization and cardiovascular diagnosis, 44(3), 1998, pp. 267-274

Abstract

The purpose of this study was to assess safety and feasibility of intracoronary delivery of reviparin using a porous balloon following percutaneous transluminal coronary angioplasty. The 2.7 mm porous balloon used in this study had 35 holes arranged in a spiral pattern. Eighteenpatients (male n = 10, female n = 8, age 63 +/- 9 years) undergoing successful PTCA in coronary arteries with a vessel diameter of 2.5 to 3.0 mm determined by online QCA (LAD = 11, RCX = 3, RCA = 4) were included. They received a bolus of 7,000 anti-Xa-IU reviparin followed by local delivery of 1,500 anti-Xa-IU in 4 mi with an injection pressure of 2 atm. The patients received additionally 10500 anti-Xa-units intravenously during the following 24 hours and a daily dose of 7000 anti-Xa-units reviparin subcutaneously for the following 28 days. Angiograms were obtained before and after PTCA, directly after local delivery, at24 hours postintervention and after 6 months. The primary success rate was 100%. Quantitative coronary angiography showed a minimum luminaldiameter of 0.42 +/- 0.14 mm before PTCA, 1.87 +/- 0.45 after PTCA, 1.67 +/- 0.43 after LDD, 1.63 +/- 0.46 after 24 hours, and 1.06 +/- 0.6after 6 months. Angiographic follow-up was obtained in all patients. No major complications occurred during the B-month follow-up period. The angiographic restenosis rate was 28% (5/18) at follow-up. This study demonstrates safety and feasibility of local intracoronary delivery of reviparin with a porous balloon following PTCA even in smaller diameter coronary arteries. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/10/20 alle ore 20:25:32