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Titolo:
CHARACTERIZATION OF THE HUMAN SDHC GENE ENCODING ONE OF THE INTEGRAL MEMBRANE-PROTEINS OF SUCCINATE-QUINONE OXIDOREDUCTASE IN MITOCHONDRIA
Autore:
ELBEHTIGREEN A; AU HC; MASCARELLO JT; REAMROBINSON D; SCHEFFLER IE;
Indirizzi:
UNIV CALIF SAN DIEGO,DEPT BIOL LA JOLLA CA 92093 UNIV CALIF SAN DIEGO,DEPT BIOL LA JOLLA CA 92093 CHILDRENS HOSP,DEPT GENET SAN DIEGO CA 00000
Titolo Testata:
Gene
fascicolo: 1-2, volume: 213, anno: 1998,
pagine: 133 - 140
SICI:
0378-1119(1998)213:1-2<133:COTHSG>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY COMPLEX-II; MUTANT-CELL LINE; HUMAN CHROMOSOME-1; DEHYDROGENASE; SUBUNIT; CENTROMERE; CLONING; C-II-3; DNA;
Keywords:
KREBS CYCLE; ELECTRON TRANSPORT CHAIN; COMPLEX II; RESPIRATION; PSEUDOGENES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
A. Elbehtigreen et al., "CHARACTERIZATION OF THE HUMAN SDHC GENE ENCODING ONE OF THE INTEGRAL MEMBRANE-PROTEINS OF SUCCINATE-QUINONE OXIDOREDUCTASE IN MITOCHONDRIA", Gene, 213(1-2), 1998, pp. 133-140

Abstract

Complex II of mitochondria contains succinate dehydrogenase and subunits to link this enzyme directly to the inner mitochondrial membrane. The four peptides of this complex are the flavoprotein (Fp) and iron-sulfur protein (Ip) of the dehydrogenase, and two integral membrane proteins referred to as C-II.3 and C-II.4. Their respective genes in mammals are SDHA, SDHB, SDHC and SDHD,(2) in order of decreasing molecularweights of the peptides. In this paper we describe the identificationof two pseudogenes and;the complete characterization and mapping of the active SDHC gene in humans. The active gene, encoding a small peptide of 15.5 kDa, has six exons and five introns extending over 35 kb. It has been mapped at position 1q21, adjacent to the pericentric heterochromatin on the long arm of chromosome 1. Approximately 1 kb of the promoter region has also been sequenced and examined for sequence motifs suggesting the binding of known transcription factors. Several potential sites for the nuclear respiratory factors NRF-1 and NRF-2 were identified. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:28:47