Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
GENETIC-MAPPING OF THE ERYTHROPOIETIN RECEPTOR GENE
Autore:
SISTONEN P; TRASKELIN AL; LEHVASLAIHO H; DELACHAPELLE A;
Indirizzi:
FINNISH RED CROSS & BLOOD TRANSFUS SERV,KIVIHAANTIE 7 SF-00310 HELSINKI 31 FINLAND UNIV HELSINKI,DEPT MED GENET SF-00290 HELSINKI 29 FINLAND FOLKHALSAN INST GENET HELSINKI FINLAND
Titolo Testata:
Human genetics
fascicolo: 3, volume: 92, anno: 1993,
pagine: 299 - 301
SICI:
0340-6717(1993)92:3<299:GOTERG>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
P. Sistonen et al., "GENETIC-MAPPING OF THE ERYTHROPOIETIN RECEPTOR GENE", Human genetics, 92(3), 1993, pp. 299-301

Abstract

We describe a novel, highly informative (polymorphism information content, PIC, = 0.86) simple sequence repeat polymorphism at the 5' end of the gene encoding the human erythropoietin receptor (EPOR) previously assigned to 19p13.2 by in situ hybridization. Fourteen different allelic size variants were identified in 12 families of the CEPH (Centre d'Etude du Polymorphisme Humain) family panel of 40 families. In pairwise linkage 16 of the 65 chromosome 19 markers reported to the CEPH database gave a lod score exceeding 3.0 when tested against EPOR. The most likely location of EPOR within a framework of 10 markers including orientation and information on reported physical assignments was LR-EPOR-cen-D19S7-D19S49-D19S75-D19S47-APOC2-qter, placing EPOR as the mostproximal of the tested loci on the short arm. On an 11-point map the position and order for all other loci except INSR were supported by the data with odds exceeding 1,000: 1. The polymorphism at the 5' end ofEPOR should provide a useful landmark marker for future mapping studies of this region.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 11:40:34