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Titolo:
IN-VITRO INHIBITION OF HEPATIC CYTOCHROME-P450 AND ENZYME-ACTIVITY BYBUTYLTIN COMPOUNDS IN MARINE MAMMALS
Autore:
KIM GB; NAKATA H; TANABE S;
Indirizzi:
EHIME UNIV,DEPT ENVIRONM CONSERVAT,TARUMI 3-5-7 MATSUYAMA EHIME 790 JAPAN EHIME UNIV,DEPT ENVIRONM CONSERVAT MATSUYAMA EHIME 790 JAPAN
Titolo Testata:
Environmental pollution
fascicolo: 2, volume: 99, anno: 1998,
pagine: 255 - 261
SICI:
0269-7491(1998)99:2<255:IIOHCA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICROSOMAL MONOOXYGENASE SYSTEM; LION EUMETOPIAS-JUBATUS; ORGANOTIN COMPOUNDS; ACCUMULATION PATTERN; ENERGY-METABOLISM; RAT THYMOCYTES; CELLS PLHC-1; IN-VITRO; FISH; TRIBUTYLTIN;
Keywords:
ENZYMATIC INHIBITION; BUTYLTINS; CYTOCHROME P450; EROD; PROD; MARINE MAMMALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
G.B. Kim et al., "IN-VITRO INHIBITION OF HEPATIC CYTOCHROME-P450 AND ENZYME-ACTIVITY BYBUTYLTIN COMPOUNDS IN MARINE MAMMALS", Environmental pollution, 99(2), 1998, pp. 255-261

Abstract

The present study attempted to examine the in-vitro inhibition of hepatic microsomal P450 content and activity by butyltins in marine mammals and discussed on their possible effects in animals in the wild. Decreases in P450 content and the activities of ethoxyresorufin O-deethylase (EROD, catalyzed by CYP1A subfamily) and penthoxyresorufin O-depentylase (PROD, catalyzed by CYP2B subfamily) by tributyltin (TBT) were observed in in-vitro experiments using hepatic microsomes of a pinniped and a cetacean. Among P450 family, EROD activity is more sensitive to TBT than P450 content and PROD activity, indicating a specific mode of action of TBT on different P450 forms. On the other hand, dibutyltin and monobutyltin have no inhibitory effect on EROD activity at concentrations less than 0.5 mM, indicating that the inhibition of enzyme activity in hepatic microsome of marine mammal is mainly by TBT. TBT concentrations that affect P450 contents and activities are above 10 times higher than the values found in the liver of various marine mammals. (C) 1998 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 03:37:25