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Titolo:
TYPE-1 AND TYPE-2 CYTOKINES IN ANTIVIRAL DEFENSE
Autore:
KARUPIAH G;
Indirizzi:
AUSTRALIAN NATL UNIV,JOHN CURTIN SCH MED RES,DIV IMMUNOL & CELL BIOL CANBERRA ACT 2601 AUSTRALIA
Titolo Testata:
Veterinary immunology and immunopathology
fascicolo: 1-2, volume: 63, anno: 1998,
pagine: 105 - 109
SICI:
0165-2427(1998)63:1-2<105:TATCIA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ECTROMELIA VIRUS; INFECTION; RESISTANCE; SUBSETS; ROLES; CELLS;
Keywords:
TYPE 1 CYTOKINE; TYPE 2 CYTOKINE; ANTIVIRAL DEFENSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
G. Karupiah, "TYPE-1 AND TYPE-2 CYTOKINES IN ANTIVIRAL DEFENSE", Veterinary immunology and immunopathology, 63(1-2), 1998, pp. 105-109

Abstract

Ectromelia virus (EV) is a natural mouse pathogen that causes a generalized infection termed mousepox, which, in the genetically resistant C57BL/6 (B6) mouse, is an inapparent disease. In contrast, BALB/c and A strain mice are highly susceptible; one infectious virus particle can result in 100% mortality. The contribution of cytokines in the induction of protective immune responses and recovery from infection with EV in B6, BALB/c and A strain mice have been. In the spleen and lymph node (LN) of resistant B6 mice, IL-2, IFN-gamma and TNF-alpha were induced rapidly with large numbers of cells producing these cytokines. Allthree cytokines were virtually absent in BALB/c and A strain mice. Nosignificant differences were found in the numbers of IL-4 producing cells in the spleen or LN of both resistant and susceptible mice. IFN-gamma-producing cells were detected in the spleen but not in the lymph node whereas IL-2-producing cells were detected only in the lymph nodeof B6 mice. Despite significant increases in the IFN-gamma mRNA levels in the LN of B6 mice, no protein was detected by immunocytochemistry. The mRNA levels of IL-2, TNF-alpha and IL-12 were also rapidly upregulated in LN of B6 mice. The rapid induction of type I cytokines strongly correlated with a potent antiviral CTL response in B6 mice. The absence of these cytokines also correlated with a complete absence or delayed induction of CTL responses to EV in both the BALB/c and A strainmice. IFN-gamma gene knock; out mice on a B6 background were as susceptible to EV as the BALB/c and A strain mice. (C) 1998 Elsevier Science B.V. All rights reserved.

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Documento generato il 30/11/20 alle ore 08:37:59