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Titolo:
DEHYDROEPIANDROSTERONE (DHEA) AND SYSTEMIC LUPUS-ERYTHEMATOSUS
Autore:
DERKSEN RHWM;
Indirizzi:
UNIV UTRECHT HOSP,DEPT RHEUMATOL & CLIN IMMUNOL F02 126,POB 85500 NL-3508 GA UTRECHT NETHERLANDS
Titolo Testata:
Seminars in arthritis and rheumatism
fascicolo: 6, volume: 27, anno: 1998,
pagine: 335 - 347
SICI:
0049-0172(1998)27:6<335:D(ASL>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE-BINDING GLOBULIN; INSULIN-RESISTANT OBESE; LOW PLASMA ANDROGENS; POSTMENOPAUSAL WOMEN; SERUM DEHYDROEPIANDROSTERONE; RECEPTOR-BINDING; T-CELLS; ORAL DEHYDROEPIANDROSTERONE; MYOCARDIAL-INFARCTION; RHEUMATOID-ARTHRITIS;
Keywords:
DEHYDROEPIANDROSTERONE; DHEA(S); SYSTEMIC LUPUS ERYTHEMATOSUS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
94
Recensione:
Indirizzi per estratti:
Citazione:
R.H.W.M. Derksen, "DEHYDROEPIANDROSTERONE (DHEA) AND SYSTEMIC LUPUS-ERYTHEMATOSUS", Seminars in arthritis and rheumatism, 27(6), 1998, pp. 335-347

Abstract

Objective: This study was performed to evaluate in vivo and in vitro data on the effects of the adrenal steroid dehydroepiandrosterone (DHEA) with emphasis on its potential use in the treatment of systemic lupus erythematosus (SLE). Methods: The literature dealing with DHEA was reviewed. Results: Initially, research on DHEA focused on effects of DHEA in relation to obesity. Over the past decade, research stimulated by associations between the physiological decline in DHEA and aging, cardiovascular disease, changes in metabolism, brain function, and immune senescense have generated insight into the many effects that DHEA or its metabolites may have. In SLE a role for sex hormones in both theetiopathogenesis and disease activity is recognized. in SLE, as in aging, low DHEA levels are frequently found, especially with corticosteroid treatment. Conclusions: Research data in the elderly, on both hormonal and immunologic effects, suggest that DHEA may become an adjunctive treatment for SLE patients. Copyright (C) 1998 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 00:18:56