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Titolo:
CEREBRAL N-ACETYLASPARTATE IS LOW IN PATIENTS WITH MULTIPLE-SCLEROSISAND ABNORMAL VISUAL-EVOKED POTENTIALS
Autore:
HEIDE AC; KRAFT GH; SLIMP JC; GARDNER JC; POSSE S; SERAFINI S; BOWEN JD; RICHARDS TL;
Indirizzi:
UNIV WASHINGTON,MED CTR,DEPT RADIOL,BOX 356004 SEATTLE WA 98195 UNIV WASHINGTON,MED CTR,DEPT RADIOL SEATTLE WA 98195 UNIV WASHINGTON,DEPT REHABIL MED SEATTLE WA 98195 UNIV WASHINGTON,DEPT SPEECH & HEARING SCI SEATTLE WA 98195 UNIV WASHINGTON,DEPT NEUROL SEATTLE WA 98195 KFA JULICH GMBH,FORSCHUNGSZENTRUM,INST MED D-52425 JULICH GERMANY
Titolo Testata:
American journal of neuroradiology
fascicolo: 6, volume: 19, anno: 1998,
pagine: 1047 - 1054
SICI:
0195-6108(1998)19:6<1047:CNILIP>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; HUMAN BRAIN; NMR-SPECTROSCOPY; OPTIC NEURITIS; DISEASE; PLAQUES; VEP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
A.C. Heide et al., "CEREBRAL N-ACETYLASPARTATE IS LOW IN PATIENTS WITH MULTIPLE-SCLEROSISAND ABNORMAL VISUAL-EVOKED POTENTIALS", American journal of neuroradiology, 19(6), 1998, pp. 1047-1054

Abstract

PURPOSE: Our purpose was to compare cerebral proton MR metabolite changes in patients with multiple sclerosis (MS) and abnormal visual evoked potentials (VEPs) with those in MS patients with normal VEPs, METHODS: Seventeen subjects with clinically definite MS were studied with VEPs and MR spectroscopic imaging, Proton MR metabolites were measured using a fast spectroscopic imaging technique called proton echo-planarspectroscopic imaging (PEPSI), Kurtzke's Expanded Disability Status Scale (EDSS) score was also ascertained for each subject to obtain a clinical rating. Twelve regions of interest within the visual pathway ofthe cerebrum were evaluated for levels of N-acetylaspartate (NAA), choline, creatine, and the presence or absence of MR-detectable lesions. RESULTS: PEPSI NAA values (water-normalized, CSF-corrected) were significantly lower in MS subjects with abnormal VEPs than in subjects,vith normal VEPs, MR-detectable lesion fractions and EDSS scores were also significantly different between the two VEP groups, but NAA comparison had a P value 100 times less than either of these measures. CONCLUSION: In patients with MS, NAA measurements in the optic pathways of the brain were sensitive to VEP abnormalities. NAA was more sensitive toVEP changes than were choline, creatine, MR-detectable lesions, and EDSS score.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 05:40:03