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Titolo:
GLUCOSE TREATMENT ATTENUATES SPATIAL-LEARNING AND MEMORY DEFICITS OF AGED RATS ON TESTS OF HIPPOCAMPAL FUNCTION
Autore:
WINOCUR G; GAGNON S;
Indirizzi:
BAYCREST CTR GERIATR CARE,ROTMAN RES INST,3560 BATHURST ST TORONTO ONM6A 2E1 CANADA TRENT UNIV,DEPT PSYCHOL PETERBOROUGH ON K9J 7B8 CANADA UNIV TORONTO,DEPT PSYCHOL TORONTO ON M5S 3G3 CANADA UNIV TORONTO,DEPT PSYCHIAT TORONTO ON M5S 3G3 CANADA UNIV QUEBEC,DEPT PSYCHOL TROIS RIVIERES PQ G9A 5H7 CANADA
Titolo Testata:
Neurobiology of aging
fascicolo: 3, volume: 19, anno: 1998,
pagine: 233 - 241
SICI:
0197-4580(1998)19:3<233:GTASAM>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
MATCHING-TO-SAMPLE; PREFRONTAL CORTEX; ALZHEIMERS-DISEASE; PERFORMANCE; LESIONS; YOUNG; IMPROVEMENT; BEHAVIOR; MICE; OLD;
Keywords:
AGING; GLUCOSE; SPATIAL MEMORY; HIPPOCAMPUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
G. Winocur e S. Gagnon, "GLUCOSE TREATMENT ATTENUATES SPATIAL-LEARNING AND MEMORY DEFICITS OF AGED RATS ON TESTS OF HIPPOCAMPAL FUNCTION", Neurobiology of aging, 19(3), 1998, pp. 233-241

Abstract

Groups of old and young rats were administered three tests of spatiallearning and memory that are known to be sensitive to hippocampal dysfunction: the radial arm maze (RAM), spatial non-matching-to-sample (SNMTS), and a spatial vs. local cue-preference task. Old rats performedworse than young rats on the RAM and SNMTS tasks, on the cue-preference task, young rats were biased to use spatial cues, whereas old rats exhibited strong preferences for distinct. local cues. Peripheral injections of glucose (100 mg/kg) improved performance by old rats on the RAM and SNMTS, which correlated with measures of glucose metabolism. Glucose treatment did not affect old rats performance on the cue-preference task. There was evidence that glucose-treatment improved performance of young rats in the RAM test, but not the other tests. The results extend the range of tasks on which glucose-induced cognitive enhancement has been demonstrated in aged rats, and provides further evidencethat memory loss resulting from hippocampal dysfunction is especiallyamenable to glucose treatment. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 01:02:04