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Titolo:
LATE-ONSET MINOR AND MAJOR DEPRESSION - EARLY EVIDENCE FOR COMMON NEUROANATOMICAL SUBSTRATES DETECTED BY USING MRI
Autore:
KUMAR A; JIN ZS; BILKER W; UDUPA J; GOTTLIEB G;
Indirizzi:
RALSTON PENN CTR,SECT GERIATR PSYCHIAT,3615 CHESTNUT ST PHILADELPHIA PA 19104 UNIV PENN,SCH MED,DEPT PSYCHIAT PHILADELPHIA PA 19104 UNIV PENN,SCH MED,DEPT RADIOL PHILADELPHIA PA 19104 UNIV PENN,SCH MED,DEPT BIOSTAT & EPIDEMIOL PHILADELPHIA PA 19104
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 13, volume: 95, anno: 1998,
pagine: 7654 - 7658
SICI:
0027-8424(1998)95:13<7654:LMAMD->2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECURRENT BRIEF DEPRESSION; PRIMARY CARE PRACTICE; LATE-LIFE DEPRESSION; CEREBRAL BLOOD-FLOW; OLD-AGE; REVERSIBLE DEMENTIA; ELDERLY INPATIENTS; ALZHEIMERS-DISEASE; SEX-DIFFERENCES; TEMPORAL LOBES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
84
Recensione:
Indirizzi per estratti:
Citazione:
A. Kumar et al., "LATE-ONSET MINOR AND MAJOR DEPRESSION - EARLY EVIDENCE FOR COMMON NEUROANATOMICAL SUBSTRATES DETECTED BY USING MRI", Proceedings of the National Academy of Sciences of the United Statesof America, 95(13), 1998, pp. 7654-7658

Abstract

The purpose of our study was to examine the neuroanatomical correlates of late onset minor and major depression and to compare them with similar measures obtained from nondepressed controls. Our study groups were comprised of 18 patients with late-onset minor depression, 35 patients diagnosed with late-onset major depression, and 30 nondepressed controls. All subjects were scanned by using a 1.5-tesla MRI scanner. Absolute whole brain volume and normalized measures of prefrontal and temporal lobe volumes were obtained and used for comparison among groups. Our findings indicate that patients with minor depression present with specific neuroanatomical abnormalities that are comparable with the major depression group but significantly different from the controls. Normalized prefrontal lobe volumes show a significant linear trend with severity of depression, with volumes decreasing with illness severity. Whole brain volumes did not differ significantly among groups. These findings have broad implications for the biology of late-life depression and suggest that there may be common neurobiological substratesthat underlie all clinically significant forms of late-onset mood disturbances.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/06/20 alle ore 01:16:01